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Updated: Feb 28, 2026

An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment

An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment

Published on: July 28, 2012

一项试点研究探讨了在膀癌中对氧酶-1组织蛋白的表达和循环水平.

David Parada¹, Alina-Iuliana Onoiu², Simona Iftimie³

¹Department of Pathology, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Av. Dr. Josep Laporte 2, 43204 Reus, Spain.

Antioxidants (Basel, Switzerland)

|February 27, 2026

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偏氧酶-1 (PON1) 和甲基氨酸酸化酶 (MTAP) 在高度膀瘤中表达的减少. 它们的综合评估可能有助于表明尿癌的瘤等级和行为.

科学领域:

在瘤学瘤学.
生物化学生物化学
分子生物学分子生物学

背景情况:

氧酶-1 (PON1) 是一种来自肝脏的抗氧化酶,关于其在人尿组织中的表达的数据有限.
在膀癌中PON1的作用在很大程度上是未被探索的.
甲基氨酸酸化酶 (MTAP) 与瘤的攻击性有关,并且可能与瘤进展中的压力途径相互作用.

研究的目的:

研究PON1和MTAP在膀癌中的表达和潜在作用.
探索瘤内PON1/MTAP表达和瘤等级之间的关系.
评估血清PON1水平及其与组织表达和瘤特征的相关性.

主要方法:

综合免疫组织化学,血清生物化学和PON1基因定型的探索性研究.
对39名患有低度 (LGUC) 和高度泌尿腺癌 (HGUC) 的患者的PON1和MTAP表达的分析.
患者组和对照组之间血清PON1度和活动的比较.

主要成果:

在高度瘤中,PON1和MTAP的表达减少,而MTAP的表达减少更为明显.
血清PON1度和活性在HGUC患者中略低于LGUC和对照组.
在不同组中,PON1多态性类似地影响了血清酶活性,患者和对照组之间的基因型频率是可比的.

关键词:

在MTAP中,MTAP是MTAP.这里是PON1的位置.膀癌:膀癌是一种癌症.免疫组织化学免疫组织化学甲基氨酸酸化酶的甲基氨酸酸酶.帕洛克索纳-1酶的使用方法

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A Murine Orthotopic Bladder Tumor Model and Tumor Detection System

A Murine Orthotopic Bladder Tumor Model and Tumor Detection System

Published on: January 12, 2017

Evaluation of the Efficacy of the H. pylori Protein HP-NAP as a Therapeutic Tool for Treatment of Bladder Cancer in an Orthotopic Murine Model

Evaluation of the Efficacy of the H. pylori Protein HP-NAP as a Therapeutic Tool for Treatment of Bladder Cancer in an Orthotopic Murine Model

Published on: May 29, 2015

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Last Updated: Feb 28, 2026

An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment

An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment

Published on: July 28, 2012

A Murine Orthotopic Bladder Tumor Model and Tumor Detection System

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Published on: January 12, 2017

Evaluation of the Efficacy of the H. pylori Protein HP-NAP as a Therapeutic Tool for Treatment of Bladder Cancer in an Orthotopic Murine Model

Evaluation of the Efficacy of the H. pylori Protein HP-NAP as a Therapeutic Tool for Treatment of Bladder Cancer in an Orthotopic Murine Model

Published on: May 29, 2015

结论:

这项研究提供了关于膀癌中内PON1表达的初步证据.
对PON1和MTAP的综合免疫组织化学评估可以作为瘤等级和生物行为的潜在生物标志物.
需要进一步的功能研究来阐明PON1和MTAP在膀癌中的机制和临床意义.