在COVID-19和结核病中调节免疫功能障碍的Glutathione-Mediated Redox调节
John Dawi1, Scarlet Affa2, Yura Misakyan1
1College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.
谷氨是一种关键的抗氧化剂,在结核病和COVID-19的免疫反应和组织健康方面起着至关重要的作用. 保持谷氨水平可能会增强对严重传染病结果的抗性.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 生物化学 生化学
背景情况:
- 结核病 (TB) 和2019年冠状病毒病 (COVID-19) 是全球重大健康威胁.
- 这两种疾病都不成比例地影响了代谢障碍,炎症和缺乏医疗保健的个体.
- 共同宿主因素,包括免疫功能障碍和氧化应激,影响疾病的严重程度.
研究的目的:
- 审查关于谷氨在免疫功能,氧化应激和结核病和COVID-19中的组织损伤中的作用的证据.
- 探索谷氨作为一种共同宿主因子,将这些传染性疾病的严重性决定因素联系起来.
- 突出谷氨在宿主导免疫疗法和弹性策略中的潜力.
主要方法:
- 实验,翻译和临床证据的整合.
- 在结核病和COVID-19中分析谷氨对免疫细胞和组织完整性的影响.
- 审查氧化还原信号通路及其与疾病严重程度的联系.
主要成果:
- 谷氨缺乏会损害结核病中的巨细胞活动和颗粒瘤结构.
- 减少的谷氨与氧化还原失衡,细胞因子风暴和COVID-19中的凝固有关.
- 在这两种感染中,谷氨酸耗尽会通过共享的免疫和血管途径加剧疾病的严重程度.
结论:
- 谷氨和氧化还原信号代表严重结核病和COVID-19中常见的脆弱性途径.
- 对于高风险人群来说,研究谷氨作为可修改的主体因子是有必要的.
- 谷氨生物学的潜力为基于弹性的策略提供了补充病原体向治疗的潜力.
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