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探索se-methylselenocysteine对GC-1/GC-2细胞的有益影响:从细胞吸收到男性繁殖中的代谢途径调节

Yiqing Lu^1,2, Xiaofei Duan^1,2, Huatao Che²

¹Institute of Crop Science, Zhejiang University, Hangzhou 310058, China.

Antioxidants (Basel, Switzerland)

|February 27, 2026

概括

甲基氨基 (MeSeCys) 通过增加和谷氨水平,增强男性生殖细胞的活力. 这种有机补充剂显示了改善男性生育能力和生殖健康的潜力.

科学领域:

生殖生物学生殖生物学
营养生物化学营养生物化学
细胞的新陈代谢

背景情况:

男性不孕症,以精子生成失败为特征,是全球重要的健康问题.
(Se) 对于正常的精子生成至关重要,并且有机形式如Se-methylselenocysteine (MeSeCys) 提供抗氧化和抗炎功效.
MeSeCys对男性生殖细胞的特定影响需要进一步研究.

研究的目的:

研究Se-methylselenocysteine (MeSeCys) 对男性生殖细胞系 (GC-1和GC-2) 的影响.
探索细胞吸收机制和对细胞内水平的影响.
阐明这些细胞中MeSeCys调节的分子通路.

主要方法:

用75μmol/L的MeSeCys对GC-1和GC-2细胞系进行24小时的治疗.
评估细胞活力和细胞内含量.
RNA测序 (RNA-seq) 和生物信息学分析以确定受影响的途径.
通过SLC7A11或LRP8通道对MeSeCys吸收的调查.

主要成果:

MeSeCys显著提高了GC-1和GC-2细胞的活力,对GC-1的影响更大.
证实了MeSeCys的吸收,导致细胞内水平升高,特别是在GC-1细胞中.
RNA-seq揭示了MeSeCys调节化合物和谷氨代谢,增加细胞内谷氨 (GSH) 水平.
在GC-1细胞中,MeSeCys专门调节mTOR通路,影响氧化还原平衡.

结论:

MeSeCys通过增强活力和氧化还原平衡,对男性生殖细胞系产生有益影响.
该化合物影响和谷的新陈代谢,可能通过GC-1细胞中的mTOR途径.
MeSeCys具有作为支持男性生殖健康的营养补充剂的潜力.

关键词:

在GC-1细胞中.在GC-2细胞中.这是一种Se-methylselenocysteine.谷氨的新陈代谢在 mTOR 路径上.男性的生殖系统是男性的生殖系统.

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