基于胃汁分析的方法对H.I.的验证 脊柱炎的诊断 诊断 诊断
Flavia Pigò1, Gian Carmine Fernicola1, Marinella Lupo1
1Gastroenterology and Digestive Endoscopy Unit, Azienda Ospedaliero-Universitaria of Modena, Viale Giardini 1355, 41126 Modena, Italy.
Diagnostics (Basel, Switzerland)
|February 27, 2026
概括
使用Endofaster®的胃汁分析提供了一种可靠的方法,用于在食道胃二透镜 (EGDS) 期间诊断Helicobacter pylori (H. pylori) 感染. 这种方法有助于为不确定的病例预留侵入性胃活检,改善患者管理.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 诊断医学 诊断医学 诊断医学
背景情况:
- 杆菌 (H. pylori) 感染虽然在下降,但由于与胃潰瘍疾病和瘤病变的关联,仍然是一个重大问题.
- 有效的诊断和治疗H. pylori对于预防相关的胃肠道病理至关重要.
- 尽管全球发病率下降,但对H. pylori的研究仍然很重要.
研究的目的:
- 通过Endofaster®评估胃汁分析的诊断性能,用于在食道胃管透镜 (EGDS) 期间检测H. pylori.
- 通过使用Endofaster®,确定阳性和阴性H. pylori结果的最佳氨度值.
- 根据Endofaster®的结果,提出基于患者管理的临床流程图.
主要方法:
- Endofaster®的诊断准确性在训练队列 (n=60) 中进行评估,并在接受EGDS的独立队列 (n=196) 中得到验证.
- 传统的组织学作为H. pylori诊断的黄金标准,在两个队列中.
- 确定氨度值,以将结果分类为正,负或不确定.
主要成果:
- 在训练队列中,分别确定了62 ppm/mL (灵敏度90%) 和100 ppm/mL (特异性95%) 的切断值,用于排除和确认H. pylori感染.
- 验证队列显示Endofaster®对H. pylori检测的灵敏度为70%,特异性为93%.
- 在15%的验证队列中观察到需要进一步确认的不确定的结果.
结论:
- 当采用决策方法时,Endofaster®在EGDS期间可以在很大程度上提供可靠的H. pylori感染诊断.
- 这种方法允许选择性地使用胃活检,将其保留给不确定的病例.
- 拟议的临床流程图可以支持对H. pylori感染的有效患者管理.
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