氧化应激和炎症生物标志物在男性不孕症:诊断价值和临床整合的叙述性审查

相关实验视频

Updated: Feb 28, 2026

04:36

Author Spotlight: A Simple and Cost-Effective Method for Leukocyte Analysis in Semen

Published on: January 19, 2024

5.6K

Athanasios Zikopoulos¹, Panagiotis Christopoulos², Theodoros Kalampokas²

¹Torbay and South Devon NHS Foundation Trust Lowes Brg, Torquay TQ2 7AA, UK.

Diagnostics (Basel, Switzerland)

|February 27, 2026

概括

炎症和氧化应激 (OS) 通过破坏精子,导致男性不育. 这些疾病的生物标志物对诊断有希望,但需要进一步验证才能在临床上使用.

科学领域:

生殖医学生殖医学
生物化学生化学
病理生理学病理生理学

背景情况:

男性不孕症是复杂的,通常无法通过传统的精液分析来解释.
炎症和氧化应激 (OS) 是导致男性生殖功能衰竭的关键因素.
反应性氧物种 (ROS) 和促炎媒介会损害精子功能和丸健康.

研究的目的:

批判性地评估男性不孕症的氧化应激和炎症生物标志物.
评估它们的诊断意义,临床效用和局限性.
探索个性化不孕症治疗的生物标志物引导方法.

主要方法:

关于男性不孕症的OS和炎症现有研究的全面审查.
评估生物标志物,如马隆迪甲 (MDA),8-基-2'-脱氧氨酸 (8-OHdG) 和炎症标志物.
对诊断值,方法变化和翻译挑战的分析.

主要成果:

操作系统和炎症创造了一个循环,加剧了精子损伤和生殖功能障碍.
特定的生物标志物 (MDA,8-OHdG,TAC,IL-6,IL-8,TNF-α) 与精液质量不佳有关.
由于缺乏标准化,目前的生物标志物在广泛的临床采用中面临限制.

结论:

运行系统和炎症生物标志物有潜力提高男性不孕症的诊断,超出传统的方法.
需要进一步的研究来克服翻译的局限性,并建立诊断值.
以生物标志物为指导的策略可以实现更精确的,基于机制的不孕症管理.

关键词:

生物标志物指导治疗细胞因子概况分析异形不孕不育不孕症是什么意思免疫调节失调免疫调节失调血清细胞精子缺陷血清细胞精子缺陷氧化还原失衡氧化还原失衡精子血中的精子.

相关概念视频

01:23

Infertility in Males

620

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...

620

01:20

Disorders of the Male Reproductive System

5.2K

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....

5.2K

01:28

Infertility in Females

4.9K

Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...

4.9K

01:41

Spermatogenesis

124.0K

Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...

124.0K

01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

651

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...

651