检测系统性炎症的可穿戴式心率变量的临床证据:系统性审查
Rukmono Siswishanto1, Detty Siti Nurdiati1, Irwan Endrayanto Aluicius2
1Department of Obstetrics and Gynecology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.
Diagnostics (Basel, Switzerland)
|February 27, 2026
概括
可穿戴心率变化 (HRV) 显示了与C反应蛋白 (CRP) 的一致反向联系,这表明它可以非侵入性地反映系统性炎症. 然而,需要更多的研究来证实其作为生物标志物的临床有用性.
科学领域:
- 生物医学工程 生物医学工程
- 生理监测 生理监测
- 数字健康数字健康
背景情况:
- 可穿戴设备通过心率变化 (HRV) 提供持续自主神经系统 (ANS) 评估.
- 系统性炎症影响ANS平衡,使HRV成为潜在的非侵入性生物标志物.
- 穿戴式HRV检测炎症的准确性需要澄清.
研究的目的:
- 系统地审查可穿戴设备衍生的HRV指数与已确定的炎症生物标志物的临床相关性.
- 评估可穿戴HRV在反映炎症状态方面的一致性和准确性.
主要方法:
- 在主要数据库 (PubMed,Scopus,Web of Science,Cochrane Library) 进行系统的文献搜索,直到2025年4月.
- 由于方法异质性,采用了没有元分析的合成 (SWiM) 框架.
- 用于数据合成的投票计数,效果方向图表和手势测试.
主要成果:
- 包括11项研究 (2419名参与者).
- SDNN (NN间隔的标准偏差) 显示出与CRP的显著反向关联 (p=0.031).
- 基于心电图的可穿戴设备表现出更一致的HRV-炎症关联,而不是光斑血学 (PPG) 设备.
结论:
- 从可穿戴设备获得的HRV,特别是来自心电图设备的SDNN,与CRP相反相关,表明其作为系统性炎症生物标志物的潜力.
- 异质性和缺乏诊断准确性数据限制了当前的临床实用性.
- 临床应用需要在标准化研究中进一步验证.
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