系统性炎症指数和疾病严重程度在急性结肠伪阻塞:一个探索性的回顾性研究
Çağrı Akalın1, Mümin Demir1, Gökhan Zaim1
1Department of General Surgery, Faculty of Medicine, Ordu University, Ordu 52200, Türkiye.
Diagnostics (Basel, Switzerland)
|February 27, 2026
概括
系统性炎症指数,如系统性炎症反应指数 (SIRI),可以帮助预测急性结肠伪阻塞 (ACPO) 的严重程度和需要手术的必要性. 需要进一步验证临床使用.
科学领域:
- 胃肠病学 胃肠病学
- 炎症标志物是一种炎症标志物.
- 败血症和炎症的发生.
背景情况:
- 急性结肠伪阻塞 (ACPO) 具有显著的发病率和死亡率风险,对监测的客观生物标志物有限.
- 放射性评估是标准的,但缺乏疾病严重程度和临床轨迹的客观标志物.
研究的目的:
- 探索复合系统性炎症指数和ACPO严重程度之间的关联.
- 研究ACPO患者手术干预的炎症标志物的预测价值.
主要方法:
- 对47名ACPO患者和50名健康对照进行了回顾性观察研究.
- 从血液计数计算中性粒细胞与淋巴细胞比率 (NLR),全身免疫炎症指数 (SII) 和全身炎症反应指数 (SIRI).
- 评估指数与随后的手术干预之间的关联.
主要成果:
- 与对照组相比,ACPO患者的SIRI和SII显著升高.
- 在ACPO队列中,NLR和SIRI显示了外科手术干预的强烈歧视 (AUCs ~0.84).
- 结合SIRI和结肠直径的模型实现了88.9%的ACPO严重性分类准确度.
结论:
- 常规血液计数的复合炎症指数与ACPO的严重程度和临床过程相关.
- 这些初步发现需要在临床应用之前在更大的前性研究中进行验证.
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