人类乳头瘤病毒感染对怀孕结果的影响:一个范围广泛的综述
Borek Sehnal1, Jan Zapletal1, Martin Hruda1
1Department of Obstetrics and Gynaecology, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University, 100 34 Prague, Czech Republic.
Diagnostics (Basel, Switzerland)
|February 27, 2026
概括
孕妇感染人类乳头瘤病毒 (HPV) 与早产和膜过早破裂的风险增加有关. 虽然观察到关联,但其他不良妊娠结果的确切因果关系需要进一步调查.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 生殖健康 生殖健康
背景情况:
- 人类乳头瘤病毒 (HPV) 是全球最常见的性传播感染.
- 与非孕妇相比,孕妇的HPV感染患病率翻了一番.
- 与HPV相关的不良妊娠结果需要检查.
研究的目的:
- 审查与宫阴道或胎盘HPV感染相关的不良妊娠结果.
- 通过分子确认,综合有关HPV在怀孕期间影响的证据.
主要方法:
- 在PubMed,EMBASE,全球健康和科克兰图书馆进行了全面的搜索.
- 包括34个记录 (28个观察性研究,1个系统审查,5个元分析) 遵循PRISMA-ScR指南.
- 关于怀孕期间HPV感染的已确定研究的专题综合.
主要成果:
- 活跃的HPV感染与早产早产膜破裂和早产分娩的风险增加显著相关.
- 由于多因素原因和有限的数据,与流产,子宫内胎儿死亡,子宫前和子宫内胎儿生长限制的关联难以确定.
- 热囊细胞和胎盘组织中的HPV存在至关重要;宫/阴道/尿道HPV与胎盘HPV相关.
结论:
- 持续的HPV感染似乎会增加早产早产膜破裂和早产的风险.
- 目前的观察证据表明,对于不良妊娠结果的关联,而不是最终的因果关系.
- 需要进一步的研究,可能检查HPV疫苗对周围并发症的影响.
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