在整个雌性循环中,对健康的母马的子宫内膜微生物群的描述
Gian Guido Donato1, Denis Necchi2, Fabrizia Gionechetti3
1Department of Veterinary Sciences, University of Turin, 10095 Grugliasco, Italy.
Animals : an open access journal from MDPI
|February 27, 2026
概括
健康的母马拥有子宫微生物群,挑战了以前的无菌子宫假设. 微生物组成在整个雌性周期内保持稳定,其中微小的变化受到周期阶段和个体不同的影响.
科学领域:
- 兽医微生物学 兽医微生物学
- 生殖免疫学 生殖免疫学
- 马类科学 马类科学
背景情况:
- 从历史上看,马匹的子宫细菌表明子宫内膜炎,假设是无菌的环境.
- 文化独立的技术揭示了母的健康子宫内膜微生物群.
- 这挑战了传统的看法,即马的子宫是无菌的.
研究的目的:
- 描述健康母马的子宫内膜微生物群.
- 研究雌性和雌性期之间的微生物组成的差异.
- 了解雌性周期对子宫微生物群落的影响.
主要方法:
- 收集了11只健康的标准种马的子宫内膜样本,这些马在雌性期和雌性期.
- 使用16S rRNA基因测序 (V1-V2区域) 进行细菌鉴定.
- 使用生物信息学工具分析微生物多样性和组成.
主要成果:
- 确定了24个细菌类和599个属,其中Firmicutes,Proteobacteria,Bacteroidota和Actinobacteriota占主导地位.
- 在期观察到显著更高的α多样性,可能与荷尔蒙变化有关.
- 发现雌性期和雌性期之间的β多样性存在实质性的重叠,这表明对整体结构的周期性影响很弱.
结论:
- 健康母马的子宫微生物群在整个雌性周期内通常是稳定的.
- 微生物组成显示出马匹特有的变化和相位依赖的微小波动.
- 激素变化和局部免疫力可能会在雌激周期期间影响子宫微生物动态.
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