相关实验视频

Updated: May 5, 2026

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform

Published on: November 30, 2016

对mTBI诱导的肠-大脑轴干扰的多奥米克分析:用于生物标志物查和机械探索的初步研究

Xianqi Zhang¹, Tingting Wang¹, Yishu Liu¹

¹Department of Forensic Science, School of Basic Medical Sciences, Central South University, Changsha 410013, China.

|February 27, 2026

概括

轻度创伤性脑损伤 (mTBI) 改变了肠道细菌和大脑代谢物,提供了潜在的法医生物标志物. 这些变化突显了肠-大脑轴的干扰和炎症,这对于理解mTBI机制至关重要.

科学领域:

神经科学是一个神经科学.
微生物学微生物学
法医医学法医医学

背景情况:

轻度创伤性脑损伤 (mTBI) 在法医中提出了诊断挑战.
mTBI可能导致急性/慢性神经精神问题,增加神经退行性疾病的风险.

研究的目的:

确定不同的肠道微生物群作为潜在的mTBI生物标志物.
探索肠道微生物群变化与mTBI后的大脑代谢物之间的关联.

主要方法:

在一个雄性Sprague-Dawley大鼠模型中诱导了mTBI.
使用16S rRNA测序分析了肠道微生物群.
通过非向的代谢学来评估大脑代谢物.

主要成果:

已识别的特定细菌种群 (例如,葡萄球菌,链球菌) 被mTBI改变.
观察到大脑代谢物的显著变化,如C24: 1 Sphingomyelin.
多种OMIC集成将微生物和代谢变化与短链脂肪酸和甘油脂代谢中断联系在一起,影响炎症因素.

结论:

mTBI会导致肠道微生物群和大脑代谢中的时间依赖性变化.
这些发现表明mTBI法医诊断和机械研究的新途径.
需要进一步的人类研究来验证生物标志物并探索肠-大脑轴因果关系.

关键词:

法医识别识别法医识别我们的肠道微生物组.代谢组代谢组的代谢轻微的创伤性脑损伤.进行多主题分析.

更多相关视频

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice

Published on: June 2, 2022

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis

Published on: July 28, 2023

相关概念视频

Introduction to the Human Microbiota

Introduction to the Human Microbiota

Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity,...

Gut-Brain Axis

Gut-Brain Axis

The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such...