结合的巴科帕,酸和胆可以保护人免受压力诱导的神经毒性
Chiara Sasia1, Giacomina Videtta1, Nicoletta Galeotti1
1Department of Neurosciences, Psychology, Drug Research and Child Health (Neurofarba), Section of Pharmacology and Toxicology, Laboratory of Neuroinflammation and Cell Senescence, University of Florence, Viale G. Pieraccini 6, 50139 Florence, Italy.
Biomedicines
|February 27, 2026
概括
这项研究表明,Bacopa monnieri,酸和胆 (BPC) 配方可减少压力诱导的神经炎症和神经毒性. BPC可能有助于预防与慢性压力相关的认知衰退.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 细胞生物学 细胞生物学
背景情况:
- 慢性压力会增加皮质醇,导致神经元损伤和记忆障碍.
- 长时间的压力会加剧促炎信号通路.
- 适应剂可以增强抗压能力和认知能力.
研究的目的:
- 调查Bacopa monnieri,酸和胆 (BPC) 配方,以减轻与压力相关的认知变化.
- 评估BPC在减轻神经炎症和神经毒性模型中的有效性.
主要方法:
- 建立了使用BV2微质细胞暴露于皮质otropin释放激素 (CRH) 的压力诱导的神经炎症的体外模型.
- 使用的SH-SY5Y细胞暴露在CRH刺激的微质条件介质或Fe/Asc中进行神经毒性测试.
- 评估了BPC对微质形态,细胞活力,压力标志物 (SIRT-1,Nrf-2,p-JNK),神经毒性和乙胆酶 (AChE) 活性的影响.
主要成果:
- BPC显著减弱了CRH诱导的微质激活,减少了细胞死亡,并恢复了SIRT-1,Nrf-2和p-JNK的水平.
- 该BPC配方证明了对CRH和Fe/Asc诱导的毒性产生神经保护作用.
- 通过使ACHE水平正常化,BPC促进了胆固醇功能,与单个成分相比,效果更好.
结论:
- 在体外,BPC配方有效地抵消与压力相关的神经炎症和神经毒性.
- BPC显示承诺作为早期认知功能障碍与慢性压力相关的治疗策略.
- 组合的BPC成分表现出协同作用,增强整体疗效.
相关概念视频
01:30Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
735
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
735
01:26Anticholinesterase Agents: Poisoning and Treatment
1.8K
Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
1.8K
01:30Indirect-Acting Cholinergic Agonists: Pharmacological Actions
1.7K
Indirect-acting cholinergic agonists, also known as anticholinesterases, exert their pharmacological effects by enhancing cholinergic transmission in various body parts, including the neuromuscular junction, autonomic cholinergic synapses, and the brain.
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
1.7K
01:23Role of Neurotransmitters in Memory
2.7K
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
2.7K
01:27Psychoneuroimmunology: Cardiovascular Disease
617
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
617
01:26Stress Prevention and Stress Management Techniques IV
288
Stress often leads to unhealthy habits like smoking, excessive drinking, and overeating, which offer short-term relief but ultimately increase long-term health risks. These behaviors create a cycle that temporarily lowers stress levels but can result in severe long-term health consequences. Breaking these habits is essential to reduce the risk of chronic diseases and improve overall well-being. Three primary changes that support better health include quitting smoking, reducing alcohol intake,...
288