与代谢功能障碍相关的脂肪性肝病的内分泌管理:叙述性综述
Muaaz Masood1, Reem Z Sharaiha2, Asma Siddique1
1Department of Gastroenterology and Hepatology, Center for Digestive Health, Virginia Mason Franciscan Health, Seattle, WA 98101, USA.
Biomedicines
|February 27, 2026
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 在全球范围内随着肥胖而上升. 内透视减肥和代谢疗法 (EBMT) 为MASLD和肥胖症的传统治疗提供了一个有希望的替代方案.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 代谢疾病 代谢疾病
背景情况:
- 全球肥胖和2型糖尿病的增加与新陈代谢功能障碍相关的性肝病 (MASLD) 患病率的上升相关.
- MASLD是导致慢性肝病的首要原因,也是美国肝移植的主要适应症.
- MASLD增加了MASH,肝硬化,癌症和死亡率的风险.
研究的目的:
- 审查关于用于肥胖和MASLD的初级和二级内镜减肥和代谢疗法 (EBMTs) 的当前文献.
- 讨论EBMTs在MASLD中的病理生理机制,疗效,安全性和患者结果.
主要方法:
- 关于初级和二级EBMTs的最新文献的叙事综述.
- 专注于治疗肥胖和MASLD的方法.
主要成果:
- 饮食和生活方式的改变往往对MASLD逆转无效.
- 药物疗法面临成本和副作用等局限性.
- 腹腔外科手术是有效的,但存在风险;EBMTs是一个有希望的替代方案.
结论:
- EBMTs正在成为管理肥胖和MASLD的安全和有效替代品.
- 对EBMTs的进一步研究对于优化患者的治疗结果至关重要.
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