适应性辐射疗法对前列腺癌中毒性的影响:一个范围审查
Miao Li1, Jerry C F Ching1, Julian T Tong1
1Department of Health Technology and Informatics, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, China.
Biomedicines
|February 27, 2026
概括
前列腺癌的适应性辐射疗法 (ART) 显示出可管理的毒性. 专门的ART系统可以减少副作用,适应性常规分离辐射疗法 (CFRT) 是对立体体辐射疗法 (SBRT) 的可行的替代方案.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 医学物理 医学物理
背景情况:
- 现有的审查缺乏对前列腺癌 (PCa) 的非MRI导向适应性辐射疗法 (ART) 毒性的关注.
- 在MRI引导和非MRI引导的ART影响之间存在有限的比较.
- 适应性常规分离辐射疗法 (CFRT) 与立体体辐射疗法 (SBRT) 在PCa毒性方面的有效性尚未得到充分研究.
研究的目的:
- 在PCa中系统地识别ART的原始文章.
- 综合评估ART对PCa毒性的影响.
- 为了比较与不同的ART方式和分成表相关的毒性.
主要方法:
- 使用的范围审查方法.
- 在2025年6月17日,在电子数据库中进行文献搜索.
- 对27篇符合资格的原创研究文章的分析.
主要成果:
- 总体中等急性毒性:GI 15.0% (第1级),1.0% (第2级);GU 47.1% (第1级),9.6% (第2级).
- 总体中等晚期毒性:GI 10.0% (第一级),2.0% (第二级);GU 29.7% (第一级),5.0% (第二级).
- 图像引导模式没有显著影响毒性;专用ART系统可以减少它. 适应性CFRT和SBRT显示了可比的毒性率.
结论:
- 适应性CFRT是SBRT适合选择PCa患者的替代方案,没有增加副作用.
- 专门的商业ART系统显示出降低毒性的潜力.
- 对形光束CT和CT引导的ART系统需要进一步的研究.
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