针对炎症性和免疫媒介性皮肤疾病的表观遗传疗法
Anna Makridou1, Dimitrios Iason Elemes2, Maria Elpida Liakou2
1School of Biology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Biomedicines
|February 27, 2026
概括
表观遗传机制将环境因素与慢性炎症性皮肤疾病 (如牛皮和亚托邦性皮肤炎) 联系起来. 针对这些表观遗传变化的治疗策略显示出希望,但需要进一步研究以获得临床应用.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 炎症性皮肤疾病涉及遗传和环境因素.
- 牛皮,亚托皮性皮肤炎 (AD),白风,全身性硬化症 (SSc),红斑狼 (LE) 和平坦 (LP) 都具有相同的慢性炎症和有限的治疗耐久性.
- 仅仅遗传因素并不能完全解释疾病的发病,爆发或复发.
研究的目的:
- 在炎症性皮肤疾病中审查表观遗传向治疗的临床前和转化证据.
- 将这些治疗策略在不同皮肤疾病中的发育成熟度进行比较.
- 识别阻碍表观遗传疗法的临床转换的差距.
主要方法:
- 综合初级临床前和转化研究.
- 专注于调节DNA甲基化,基因素修饰和非编码RNA的干预措施.
- 在牛皮,AD,白风,SSc,LE和LP中的治疗发展状态的比较.
主要成果:
- 表观遗传机制 (DNA甲基化,基因组修饰,非编码RNA) 提供了环境和皮肤疾病表型之间的联系.
- 针对表观遗传调节的治疗策略正在研究中.
- 研究对牛皮和AD最先进,对其他疾病的证据有限.
结论:
- 表观遗传调制具有治疗炎症性皮肤疾病的潜力.
- 在研究和临床翻译方面存在重大差距,特别是在白风,SSc,LE和LP方面.
- 弥合这些差距对于开发有效的表观遗传疗法至关重要.
相关概念视频
Clinical Applications of Epidermal Stem Cells
3.4K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.4K
Inflammatory Response
17.5K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
17.5K
Inflammatory Bowel Disease IV: Pharmacological Management
860
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
860
Tumor Immunotherapy
2.1K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.1K
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
604
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
604
T Cell Types and Functions
2.9K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.9K


