增强口腔透的液体配方的表征:探索关键属性
Ariana Sena1, Andreia Tabanez1, Francisca Bastos1
1Bluepharma-Indústria Farmacêutica S.A., São Martinho do Bispo, 3045-016 Coimbra, Portugal.
Biomedicines
|February 27, 2026
概括
优化口腔药物输送需要配方,增强粘度和粘度,以延长停留时间. 较高的氧烯纤维素 (HPC) 度改善了这些特性,导致药物流量增加,并且增加了口腔菌产品的疗效.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 生物材料是一种生物材料.
背景情况:
- 口服给药绕过了第一通代谢,提高了药物的生物可用性与口服途径相比.
- 有效的口腔药物递送依赖于与口腔粘膜保持长时间接触的配方.
- 粘度和粘度是影响药物在口腔部位停留时间的关键配方属性.
研究的目的:
- 为了研究基烯基纤维素 (HPC) 度对口腔配方特性的影响.
- 为了将配方属性 (附着性,粘度) 与药物的停留时间和透率相关联.
- 评估配方和透增强剂对药物输送的联合作用.
主要方法:
- 用不同的HPC度制备和表征粘附度,粘度和停留时间的口腔配方.
- 在体外和体外的药物透研究使用仿生膜和猪口腔组织进行.
- 将透增强剂化 (BKC) 纳入,以评估其对药物运输的影响.
主要成果:
- 增加HPC度增强了配方粘合力和粘度,2%的HPC显示最佳结果.
- 较高的HPC度与在口腔粘膜中药物停留时间显著长的相关性.
- 尽管表面透率略有下降,但由于居住时间的改善,药物流量增加了1.6倍,HPC为2%.
- 化进一步提高了药物透率,增加了表面透率的1.5倍 (相对于2%的HPC) 和2.5倍 (相对于没有HPC).
结论:
- 口腔液体制剂的疗效受到居住时间和药物透之间的相互作用的显著影响.
- 附着性和粘度协同增强留时间,这对于有效的口腔药物递送至关重要.
- 在口腔粘膜药物产品的开发过程中,对粘度和粘度的系统评估至关重要.
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