在患有心脏代谢风险因素的患者中,状年和炎症指数之间的关系
Paula Cristina Morariu1, Alexandru Florinel Oancea1, Maria Mihaela Godun1
1Department of Internal Medicine, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.
Biomedicines
|February 27, 2026
概括
在心脏代谢患者中,炎症标志物不能独立预测轻微的额头环状化 (MAC). 相反,年龄和葡萄糖异常是主要的驱动因素,这表明炎症反映了整体代谢状态,而不是MAC本身.
科学领域:
- 心脏病学 心脏病学
- 内部医学 内部医学
- 生物标志物 生物标志物
背景情况:
- 中心环状化 (MAC) 与系统性动脉样硬化和心脏代谢风险因素有关.
- 血液炎症指数和MAC之间的关系,特别是在心脏代谢背景下,仍然不完全理解.
研究的目的:
- 在调整心脏代谢因素后,调查血液炎症指数是否独立与轻微的额头环状化 (MAC) 相关.
- 确定在已确立心脏代谢风险的人群中轻度MAC的主要独立预测因素.
主要方法:
- 一项前性,横截面研究将轻度MAC的成年人与没有MAC的成年人进行了比较,但不包括具有重大并发症的个人.
- 分析了C反应蛋白 (CRP),中性粒细胞与淋巴细胞的比率 (NLR),全身炎症反应指数 (SIRI) 和淋巴细胞与白细胞的比率 (LLR) 与MAC状态相关.
- 多变量逻辑回归模型被用来评估综合心脏代谢调整后的独立关联.
主要成果:
- 在205名患者中,134人患有轻度的MAC. 患有MAC的患者年龄较大,心脏代谢负担较高 (低血糖,高血压,肥胖).
- 不调整的炎症标志物 (CRP,NLR,SIRI,LLR) 在MAC组之间有所不同 (p ≤0.039).
- 在多变量调整后,没有炎症标志物独立与MAC相关. 年龄 (ORs 1.056-1.063),糖尿病前期 (ORs 2.43-3.63) 和2型糖尿病 (ORs 5.91-6.19) 一致相关 (p ≤ 0.001).
结论:
- 在这个队列中,炎症指数在心脏代谢调整后没有显示与轻度MAC的独立关联.
- 研究结果表明,炎症标志物主要反映了整体心脏代谢环境,而不是特定于MAC.
- 年龄和葡萄糖代谢异常是轻度MAC的主导独立预测因素,突出了代谢功能障碍在其发病过程中的作用.
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