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果实提取物作为AMPK相关的线粒体生物能调节器在皮肤衰老模型中

Rui Ye^1,2,3, Qianqian Wang⁴, Le Du^2,3

¹Department of Dermatology & Venerology, Center of Cosmetic Safety and Efficacy Evaluation and NMPA, Key Laboratory for Human Evaluation and Big Data of Cosmetics, West China Hospital Sichuan University, Chengdu 610041, China.

|February 27, 2026

概括

角兽官员植物水果提取物 (COFE) 通过增强线粒体功能来促进细胞能量代谢,并对抗皮肤衰老. 这种天然成分在实验室模型和临床试验中都显示出显著的抗衰老作用.

科学领域:

皮肤化学皮肤化学
细胞生物学细胞生物学
衰老研究研究衰老研究

背景情况:

线粒体功能障碍是皮肤衰老的一个关键因素.
增强细胞能量代谢对于抗衰老皮肤化品创新至关重要.
科纳斯官员植物果实提取物 (COFE) 被研究其调节线粒体功能的潜力.

研究的目的:

调查COFE调节线粒体功能和抵消光氧化应激的能力.
在皮肤相关的模型和临床环境中评估COFE的抗衰老作用.

主要方法:

在人类皮肤纤维细胞中评估了线粒体的生物能量 (AMPK酸化,ATP,NAD+/NADH,ΔΨm).
使用RNA-seq和qPCR分析了转录组变化.
评估了COFE对炎症,水合,增殖和屏障标志物的影响,在一个重建的人类表皮模型中用UVA和视网醇挑战了COFE.
进行了一项体内研究,使用1%的COFE眼.

主要成果:

COFE激活了AMPK信号传递和调高了OXPHOS基因,显著增加了ATP,NAD+/NADH比率和ΔΨm.
在表皮模型中,COFE降低了炎症 (IL-1α),改善了水分 (AQP3),增殖 (Ki67) 和屏障功能 (PKCα).
在体内,COFE眼部奶油在28天内显著改善了水分,屏障功能,发红,皮肤色调,纹,弹性和周围眼圈轮.

结论:

COFE作为一个AMPK相关的线粒体生物能调节器.
咖啡因增强细胞能量代谢,减轻光氧化应激.
COFE 是一种有前途的抗衰老成分,用于皮肤化品应用,由机械学和临床数据支持.

关键词:

这就是AMPKK.这就是ATPATPATP ATP.官方的角兽 (Cornus officinalis) 是一个植物.奥克斯福斯 (OXPHOS) 是一个纤维细胞细胞是什么?

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