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基因和基因功能与猪的形态,生产,繁殖和尸体质量特征相关:一种功能生物信息学方法

Wilber Hernández-Montiel¹, Víctor M Meza-Villalvazo², Dany A Dzib-Cauich³

¹Instituto de Agroingeniería, Universidad del Papaloapan, Av. Ferrocarril s/n, Ciudad Universitaria, Campus Loma Bonita, Loma Bonita 68400, Mexico.

Current issues in molecular biology

|February 27, 2026

概括

这项研究使用生物信息学来分析影响猪生长和繁殖等特征的基因. 它确定了关键途径,如SMAD信号传输,以改善生猪养殖的标记器辅助选择 (MAS).

科学领域:

基因组学和生物信息学
动物育种与遗传学
分子生物学分子生物学

背景情况:

了解基因功能对于改善家猪经济重要特征至关重要.
标记器辅助选择 (MAS) 依赖于识别与形态,生产力,繁殖和尸体质量等特征相关的基因.

研究的目的:

使用生物信息学方法对影响猪关键经济特征的基因进行功能性特征.
确定与这些特征相关的分子机制和代谢途径.
为优化生猪养殖中标记辅助选择 (MAS) 策略提供见解.

主要方法:

从116项 (2000-2024) 与猪特征相关的研究中编制的基因数据.
使用DAVID和clusterProfiler (R) 进行了新的功能丰富分析,并进行了FDR校正.
使用STRING. 探索蛋白质与蛋白质相互作用 (PPI) 网络.

主要成果:

识别了经常报告的基因,如VRTN (乳头数),HOMER1 (腿部强度) 和BMPR1B (垃圾大小).
丰富基因本体学 (GO) 术语包括转录的积极调节,状细胞分化和SMAD信号传递 (FDR = 7.34 × 10−7).
PPI网络突出显示了参与信号和免疫调节的基因.

结论:

生物信息学分析提供了对猪经济特征背后的基因的综合功能概述.
已识别的类通路,特别是SMAD/TGF-β信号传递,至关重要.
这些发现支持制定更有效的MAS策略,用于养猪计划.

关键词:

生物信息学是一种生物信息学.尸体质量尸体质量基因本体学基因本体学猪遗传学猪遗传学生殖特征生殖特征选择的选择选择的选择.

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