COVID-19和癌症之间的基因共享签名通过In Silico病例控制分析确定
Ammar Yasir Ahmed Ahmed1, Sevinç Akçay2
1College of Pharmacy, University of Al Maarif, Al Anbar P.O. Box 55431, Iraq.
Genes
|February 27, 2026
概括
这项研究揭示了严重的COVID-19和攻击性癌症 (如三阴性乳腺癌) 之间的共同分子通路. 识别这些共同点可能有助于开发新的治疗方法,用于癌症患者面临病毒感染.
科学领域:
- 生物信息学是一种生物信息学.
- 在瘤学瘤学.
- 病毒学 病毒学
背景情况:
- 癌症患者因恶性瘤和治疗的免疫抑制而表现出更高的感染易感性.
- COVID-19大流行强调了这种脆弱性,特别是在攻击性癌症中,如三阴性乳腺癌 (TNBC) 和清细胞细胞癌 (ccRCC).
- 癌症进展和COVID-19严重程度之间的分子联系尚未得到充分理解.
研究的目的:
- 为了确定COVID-19和TNBC,乳腺癌和ccRCC之间的共享分子签名.
- 阐明癌症和COVID-19严重程度之间的相互作用背后的分子机制.
- 为了解病毒与癌症相互作用和潜在的治疗点提供一个框架.
主要方法:
- 在公开可用的转录基因数据集的in silico案例对照分析.
- 在轻度/重度COVID-19和癌症类型之间识别差异表达基因 (DEGs).
- 构建蛋白质-蛋白质相互作用 (PPI) 网络,基因本体学 (GO),KEGG通路,miRNA和转录因子 (TF) 分析.
主要成果:
- 确定了与免疫调节,炎症和瘤进展相关的共享枢纽基因 (例如,TNBC中的IGF1,MMP9,NOTCH1;乳腺癌中的TOP2A,PXN,CCNB1;ccRCC中的ASPM,TTK).
- 包括MAPK信号传递和细胞因子-细胞因子受体相互作用在内的融合途径被揭示出来.
- 关键的调节分子 (例如,miR-145-5p,NFKB1,TP53) 调节了病毒和瘤过程,严重的COVID-19显示了增强的炎症信号.
结论:
- 确定了共同的分子和监管特征,将严重的COVID-19与侵袭性癌症联系起来.
- 突出了持续的免疫激活和改变的免疫沟通作为共同的主题.
- 提供了病毒与癌症相互作用的假设生成框架,可能为脆弱癌症群体的生物标志物发现和免疫集中治疗提供信息.
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