微生物组,表观遗传学和营养因素在塑造围产期怀孕结果中的作用
Miljana Z Jovandaric1, Sandra Babic2, Milos Milincic2
1Department of Neonatology, Clinic for Gynecology and Obstetrics, University Clinical Center of Serbia, 11000 Belgrade, Serbia.
International journal of molecular sciences
|February 27, 2026
概括
母亲的营养和肠道微生物群通过调节表观遗传编程和氧化应激来影响胎儿的发育. 了解这些联系可以导致个性化策略,以改善新生儿的结果.
科学领域:
- 围产儿医学 围产儿医学
- 营养科学 营养科学
- 微生物组研究 微生物组研究
背景情况:
- 孕产妇的营养和肠道微生物对胎儿发育至关重要.
- 这些因素影响免疫信号,氧化平衡和表观遗传编程.
- 这些母性特征对围产期的结果产生了重大影响.
研究的目的:
- 审查有关母亲饮食,肠道微生物组及其对围产期健康的影响的文献.
- 探索涉及的分子和代谢网络.
- 确定改善新生儿结果的潜在策略.
主要方法:
- 在PubMed,Scopus,Cochrane图书馆和科学网络 (2010-2025) 的系统文献搜索.
- 关键词包括母亲的饮食,肠道微生物组,表观遗传学,氧化应激,ROS,SCFA,胎盘功能和围产期结果.
- 精选全文,同行评审的英语文章.
主要成果:
- 母亲的饮食模式和微生物组代谢物影响胎盘功能,胎儿生长和新生儿健康.
- 确定了关键的分子和代谢网络,将微生物组,表观遗传学和营养联系起来.
- 有证据表明,这些因素是围产期健康的中央调节者.
结论:
- 孕产妇营养,肠道微生物组和表观遗传学之间的相互作用对围产期健康至关重要.
- 特定网络的有针对性的调制为个性化干预提供了基础.
- 这些策略旨在增强胎儿发育和改善新生儿的结果.
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