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Updated: Feb 28, 2026

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在质瘤中循环miRNA的诊断潜力:系统性审查和元分析

Aizere Khassenova¹, Zhamilya Seitkanova¹, Alissa Loskutova²

¹Biology Department, School of Sciences and Humanities, Nazarbayev University, Kabanbay Batyr Ave., 53, Astana 010000, Kazakhstan.

International journal of molecular sciences

|February 27, 2026

概括

血液循环中的微RNAs (miRNAs) 显示出作为诊断生物标志物用于质瘤识别的前景. 这一元分析表明了它们的潜力,尽管由于研究异质性,需要进一步的研究.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物标志物发现发现

背景情况:

质瘤是具有挑战性的内瘤,诊断和治疗选择有限.
循环血液的microRNAs (miRNAs) 是在病理条件下表达变化的调节分子,具有检测潜力.

研究的目的:

评估血液循环中的miRNAs在所有等级的质瘤识别中的诊断潜力.
通过元分析综合现有研究的证据.

主要方法:

在PubMed,Web of Science和Scopus数据库中进行系统的文献搜索,直到2025年10月.
包括比较质瘤患者和健康对照者的miRNA水平的研究,报告灵敏度和特异性.
使用双变的随机效应模型进行元分析,用I2统计,子组分析,元回归,Deeks' funnel plot 和 Fagan's nomogram 来评估异质性.

主要成果:

对31份报告 (2299名质瘤患者,1719名对照患者) 的分析显示,综合敏感度为0.83,特异性为0.88.
诊断几率比为35,SROC分析的曲线下面面积 (AUC) 为0.92.
在分析的研究中观察到显著的异质性.

结论:

血液循环中的miRNAs显示出作为结核瘤诊断的非侵入性生物标志物的潜力.
高异质性需要谨慎的解释,表明结果是探索性的,需要进一步验证.

关键词:

生物标志物生物标志物诊断诊断诊断诊断诊断质母细胞瘤 (glioblastoma) 是一种质瘤质瘤是一种这是一个小RNARNA.

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相关概念视频

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...