相关实验视频

Updated: Feb 28, 2026

An Ex vivo Model of an Oligodendrocyte-directed T-Cell Attack in Acute Brain Slices

An Ex vivo Model of an Oligodendrocyte-directed T-Cell Attack in Acute Brain Slices

Published on: February 5, 2015

寡头质细胞是多发性硬化症及其动物模型病变发生过程中的积极参与者

Min Li Lin^1,2, Wensheng Lin^1,2

¹Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.

International journal of molecular sciences

|February 27, 2026

概括

曾经被认为是被动的橄球体现在已知是多发性硬化症 (MS) 和其动物模型实验性自身免疫脑膜炎 (EAE) 的活跃参与者. 本综述强调了它们在这些中枢神经系统自身免疫性疾病中的动态作用.

科学领域:

神经免疫学神经免疫学
脱线性疾病脱线性疾病
中枢神经系统 (CNS) 病理生理学中枢神经系统 (CNS) 病理生理学

背景情况:

多发性硬化症 (MS) 和实验性自身免疫脑膜炎 (EAE) 的特征是中枢神经系统的自身免疫性炎症和脱髓化.
传统上,橄干细胞被认为是MS和EAE的自身免疫攻击的被动目标.
新出现的证据表明,寡二细胞积极促进疾病的发病.

研究的目的:

审查最近关于寡细胞在MS和EAE中的活性作用的研究.
挑战长期以来的观点,将寡细胞视为纯粹被动的目标.
突出中枢神经系统自身免疫性疾病中寡类细胞的动态和参与性功能.

主要方法:

关于MS和EAE中的寡腺细胞功能的最近研究的文献综述.
综合发现,证明活跃的寡类细胞参与.
对实验证据的分析,以支持小基细胞参与病变的分析.

主要成果:

在中枢神经系统的自身免疫性炎症期间,寡二细胞表现出积极的反应.
这些细胞不仅仅是目标,而且是MS和EAE的动态参与者.
最近的研究揭示了寡细胞参与的具体机制.

结论:

在MS和EAE中对寡类细胞作用的理解已经显著发展.
氧基细胞是这些脱髓化疾病的病原体的积极贡献者.
未来的研究应该进一步探索这些治疗潜力的积极作用.

关键词:

脱化是脱化的一种.实验性的自身免疫性脑膜炎.一个内在的寡聚细胞缺陷.多发性硬化症多发性硬化症骨髓蛋白是什么意思骨髓蛋白是什么意思一个小分子基细胞.

更多相关视频

Generation of Oligodendrocytes and Oligodendrocyte-Conditioned Medium for Co-Culture Experiments

Generation of Oligodendrocytes and Oligodendrocyte-Conditioned Medium for Co-Culture Experiments

Published on: February 9, 2020

Preparation of Rat Oligodendrocyte Progenitor Cultures and Quantification of Oligodendrogenesis Using Dual-infrared Fluorescence Scanning

Preparation of Rat Oligodendrocyte Progenitor Cultures and Quantification of Oligodendrogenesis Using Dual-infrared Fluorescence Scanning

Published on: February 17, 2016

相关概念视频

T Cell Types and Functions

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

Nervous Tissue: Myelin

Nervous Tissue: Myelin

The myelin sheath is a multilayered lipid and protein covering that insulates the axon of a neuron, enhancing the speed of nerve impulse conduction. Axons without this sheath are referred to as unmyelinated. Two types of neuroglia, Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS) are responsible for producing myelin sheaths.
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...