精神分裂症是生物障碍的疾病:叙述审查和潜在干预措施
Adonis Sfera1, Nyla Jafri2, Jacob Anton3
1Department of Psychiatry, Loma Linda University, Patton State Hospital, Patton, CA 92369, USA.
精神分裂症可能涉及肠道衰老和屏障功能障碍,允许微生物转移激活大脑免疫细胞并减少灰质. 针对屏障完整性的干预措施可能具有治疗潜力.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 严重的精神疾病,如精神分裂症,与过早的脑细胞衰老,免疫细胞激活和灰质损失有关.
- 基碳化合物受体 (AhR) 调节屏障完整性和细胞衰老,特别是在肠道和血脑屏障中.
研究的目的:
- 探索一种潜在的机制,将精神分裂症与微生物迁移,微质激活和灰质减少联系起来.
- 讨论维持屏障功能和预防中枢神经系统病理的干预措施.
主要方法:
- 审查关于精神分裂症病理生理学,肠-大脑轴,阿里碳化合物受体信号传递和屏障功能的现有文献.
- 分析涉及微生物转移和神经炎症的潜在途径.
主要成果:
- 病理性AhR激活可能促进肠道衰老和屏障透性,促进微生物转移.
- 转移的微生物或它们的产物可以触发微质激活,并有助于减少精神分裂症的灰质体积.
结论:
- 保持肠道和血脑屏障的完整性对于预防精神分裂症相关的神经炎症和病理学至关重要.
- 调节亚利碳化合物受体和采用生物物理策略显示出治疗干预的前景.
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