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在大动脉疾病中氧化应激诱导的DNA损伤反应途径:对炎症和血管退化的影响

Sebastian Krych1,2, Julia Gniewek2, Marek Kolbowicz3

  • 1Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, School of Medical Sciences in Zabrze, Medical University of Silesia, Marii Skłodowskiej-Curie 9, 41-800 Zabrze, Poland.

International journal of molecular sciences
|February 27, 2026
PubMed
概括

氧化应激会导致大动脉细胞中的DNA损伤,激活DNA损伤反应 (DDR). 失调的DDR通过促进炎症和壁退化加速大动脉动脉瘤等大动脉疾病.

关键词:
对DNA损伤的反应反应修复DNA的修复DNA的修复一个orthopathies的情绪.动脉炎是一种动脉炎.基础切除修复的基础切除修复细胞衰老 细胞衰老这是一种炎症炎症炎症炎症.氧化应激是一种氧化应激.血管光滑肌肉细胞的细胞.

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