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梅尼耶氏病的循环线索:患者血液中细胞自由DNA升高和促炎特征

Marijana Sekulic¹, Swethiny Kobivasan², Stavros Giaglis¹

¹Department of Biomedicine, University Hospital Basel, 4031 Basel, Switzerland.

International journal of molecular sciences

|February 27, 2026

概括

在Ménière中,无细胞DNA (cfDNA) 和炎症媒介.

科学领域:

耳鼻喉科和血管生物学

背景情况:

梅尼尔病 (MD) 与血液迷宫屏障功能障碍有关,但内皮损伤的潜在机制尚未完全理解.
循环因素,如无细胞DNA (cfDNA) 和炎症调解剂,可能在MD的血管应激和屏障破坏中发挥作用.

研究的目的:

调查血cfDNA和炎症媒介对内皮损伤和血液迷宫屏障破坏在梅尼耶尔病的贡献.

主要方法:

在MD患者和健康对照中量化血cfDNA水平.
使用暴露在患者血中的人体血管内皮细胞评估内皮质屏障功能.
对内皮细胞毒性,F-actin组织,syndecan-1表达和炎症媒介的分析 (IL-1β,CCL3,CCL27).

主要成果:

在MD患者的血中发现显著升高的cfDNA水平.
MD血损害了内皮屏障功能,增加了细胞毒性,并导致了葡萄糖的降解 (降低了syndecan-1).
DNase I治疗部分扭转了这些影响,突出了cfDNA的作用. 在MD血中观察到升高的IL-1β,CCL3和CCL27.

结论:

血cfDNA和炎症调解剂协同诱导内皮损伤,细胞骨重塑和葡萄糖脱落,削弱了MD中的血液迷宫屏障.
向cfDNA或保存糖核糖体可能为Ménière病提供新的治疗策略.
基于cfDNA的标记物显示出监测MD内皮损伤的潜力.

关键词:

梅尼耶尔病是梅尼耶尔病.血液迷宫屏障是血液迷宫的屏障.没有细胞的DNA DNA.细胞因子细胞因子体内皮质的葡萄糖.

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