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在保加利亚感染个体中对Enterobius vermicularis (Rhabditida:Oxyuridae,Linnaeus,1758) 的基因型分析:第一个家族遗传研究

Eleonora Kaneva¹, Reneta Dimitrova², Nina Tsvetkova¹

¹Department of Parasitology and Tropical Medicine, National Centre of Infectious and Parasitic Diseases, 26 Yanko Sakazov Blvd., 1504 Sofia, Bulgaria.

International journal of molecular sciences

|February 27, 2026

概括

保加利亚的虫病主要是由虫Enterobius vermicularis的单一遗传类型 (基因型B) 占主导地位,其遗传多样性非常低. 这表明最近的引入或扩张对于东南欧的公共卫生控制至关重要.

科学领域:

寄生虫学的寄生虫学
分子生物学分子生物学
人口遗传学人口遗传学

背景情况:

由Enterobius vermicularis引起的虫病是一个全球性的健康问题.
在东南欧,特别是保加利亚,E. vermicularis的遗传数据有限.

研究的目的:

来自保加利亚的E. vermicularis分离物的第一个分子和遗传学表征.
分析该地区松鼠种群的遗传结构和多样性.

主要方法:

从128名患有肠病的个体收集了近带样本.
进行了嵌套PCR,针对线粒体的cox1基因进行分子识别.
使用最大概率和人口遗传指数计算进行了家族遗传分析.

主要成果:

所有128个保加利亚分离物属于基因型B,与欧洲和亚洲序列集群.
观察到非常低的遗传多样性 (Hd = 0.1507,π = 0.00082).
在所有地区,单一的主导类型 (Hap_1) 占样本的92.2%;Tajima的D显著负.

结论:

基因型B的主导地位和低遗传多样性表明,最近在保加利亚引入或克隆扩张了E. vermicularis.
调查结果为监测巴尔干地区的传播和控制策略提供了基线数据.

关键词:

虫 (Enterobius vermicularis) 是一种有色的植物.这就是COX1基因.肠杆菌病 (enterobiasis) 是一种致虫病.基因型B 基因型B 基因型B 分子流行病学分子流行病学遗传学分析遗传学分析

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