肠道微生物群的多样性和组成跨变化类型和核桃补充剂的影响 - 一项观察和干预研究
Sophie Bucher Della Torre1, Aurélien Clerc1, Pascal Wild2
1Department of Nutrition and Dietetics, Geneva School of Health Sciences, HES-SO University of Applied Sciences and Arts Western Switzerland, 1227 Geneva, Switzerland.
International journal of environmental research and public health
|February 27, 2026
概括
轮班工作可能会破坏肠道微生物群 (GM) 的多样性,特别是在夜班. 核桃补充剂可能有助于保护轮班工人中的转基因多样性,这表明了潜在的肠道健康营养策略.
科学领域:
- 微生物学 微生物学
- 营养科学 营养科学
- 职业健康 职业健康 职业健康
背景情况:
- 轮班工作通过昼夜干扰和生活方式因素与慢性疾病有关.
- 在轮班工人中,越来越多地发现肠道微生物群 (GM) 的变化.
- 了解轮班工人中的转基因变异对于开发健康干预措施至关重要.
研究的目的:
- 调查不同周班轮流轮班工人肠道微生物群的多样性和组成.
- 评估核桃补充剂对肠道微生物群的影响.
- 探索饮食质量与肠道微生物群多样性之间的相关性.
主要方法:
- 一个人体内研究设计,比较早晨,下午和夜班的肠道微生物群.
- 16S rRNA测序被用来分析肠道微生物群的多样性和组成.
- 一个为期三周的观察期,然后是为期三周的核桃补充干预.
主要成果:
- 肠道微生物群的组成在轮班和在核桃补充后保持稳定.
- 在观察阶段,在夜班结束时观察到细菌多样性的显著减少.
- 在夜班期间这种多样性减少在核桃补充阶段并不存在.
- 在更健康的饮食和更大的平均肠道微生物群多样性之间发现了正相关性.
结论:
- 虽然整体肠道微生物群组成稳定,但夜班可能会减少细菌的多样性.
- 核桃补充剂可能有助于缓解夜班期间肠道微生物群多样性的下降.
- 针对性营养策略,如核桃摄入量,显示保持轮班工人的肠道健康的希望.
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