微生物群与宿主界面上的β-葡萄酶:自然产品的双重调节作用和精确调节
Jialu Shen1, Shuai Xu1, Qingyu Zhao1
1State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Molecules (Basel, Switzerland)
|February 27, 2026
概括
肠道微生物β-glucuronidase (GUS) 影响药物代谢和健康. 自然产品有潜力调节GUS活动,以开发针对各种疾病的向疗法.
科学领域:
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
- 生物化学 生物化学
背景情况:
- 肠道微生物β-葡萄糖酶 (GUS) 在宿主-微生物群界面上化葡萄糖合物.
- 失调的GUS活性与药物毒性,炎症和癌症有关.
- GUS在健康和疾病中的双重作用,以及它与天然产品的相互作用,往往被低估.
研究的目的:
- 审查GUS研究的进展,涵盖其结构,功能和对宿主健康的影响.
- 突出自然产品作为GUS活动的调节器.
- 为开发针对GUS的基于微生物群的疗法提供基础.
主要方法:
- 关于GUS的结构,药理和微生物学研究的文献综述.
- 对天然产品与GUS相互作用的分析,包括直接抑制和间接调节.
- 整合多样化的研究观点,以告知治疗策略.
主要成果:
- GUS表现出结构多样性和功能复杂性,显著影响宿主平衡.
- 自然产品可以通过直接抑制或通过改变肠道微生物群组成来调节GUS活性.
- 这些调制影响药物的疗效,毒性和内源代谢物水平.
结论:
- GUS是治疗干预的关键目标.
- 天然产品在开发GUS精密调制器方面表现有前途.
- 进一步的研究可以通过针对GUS和肠道微生物群来推进个性化疗法.
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