对接受生物治疗的牛皮患者进行探索性回顾性评估
Andrada-Luciana Lazar1,2, Sorana D Bolboacă3, Adrian-Lucian Baican4
14th Medical Clinic, Internal Medicine Department, "Iuliu Haţieganu" University of Medicine and Pharmacy Cluj-Napoca, 400347 Cluj-Napoca, Cluj, Romania.
Medicina (Kaunas, Lithuania)
|February 27, 2026
概括
生物疗法显著改善了罗马尼亚患者的牛皮结局. 像抗IL-17和抗IL-23这样的较新的药物显示出比抗TNF疗法更高的疗效,治疗切换的次数更少.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 牛皮是一种慢性炎症性皮肤疾病,影响疾病的严重程度和生活质量.
- 生物疗法提供了显著的好处,但关于罗马尼亚患者群体的数据很少.
- 了解罗马尼亚的生物治疗模式和结果对于优化患者护理至关重要.
研究的目的:
- 来自罗马尼亚特兰西瓦尼亚的牛皮病患者的特征.
- 评估生物疗法 (抗TNF,抗IL-17,抗IL-23) 对疾病严重性的影响.
- 评估治疗转换,生活质量 (DLQI) 和实验室生物标志物.
主要方法:
- 这是一项回顾性探索性研究,利用从罗马尼亚克卢日纳波卡的两个中心定期收集的医疗数据.
- 对115名用抗TNF,抗IL-17或抗IL-23生物药物治疗的患者进行评估.
- 分析患者人口统计,先前的治疗,并发症,疾病严重程度得分 (PASI) 和生活质量.
主要成果:
- 接受抗IL-17或抗IL-23治疗的患者在诊断时比接受抗TNF治疗的患者年龄更大 (p=0.0001).
- 头皮 (58.3%) 和指甲 (36.5%) 的参与是常见的;心脏代谢并发症是普遍存在的.
- 与抗TNF (p=0.045) 相比,抗IL-17/抗IL-23疗法在36周表现出更好的结果;由于有效性降低,抗TNF的切换率更高 (57.8%).
结论:
- 生物疗法显著改善了罗马尼亚患者的牛皮严重程度和生活质量.
- 与抗TNF药物相比,抗IL-17和抗IL-23生物药物表现出更好的疗效和更低的切换率.
- 不管病变的局部位置如何,使用生物药物观察到临床改善.
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