在过敏结膜炎中空气污染,花粉和室内暴露:系统性审查
Clara Martinez-Perez1, Ana Paula Oliveira2,3
1Department of Physics of Condensed Matter, Optics Area, University of Seville, Reina Mercedes S/N, 41012 Seville, Spain.
Life (Basel, Switzerland)
|February 27, 2026
概括
环境暴露,如空气污染和过敏原,显著加剧过敏结膜炎 (AC). 了解这些联系是预防和管理这种常见的眼睛疾病的关键.
科学领域:
- 眼科医生 眼科 眼科
- 环境健康 环境健康
- 免疫学 免疫学 免疫学
背景情况:
- 环境因素被认为是眼睛表面炎症的关键驱动因素.
- 各种环境暴露对过敏结膜炎 (AC) 的综合影响需要全面的综合.
研究的目的:
- 系统地审查和综合证据,将空气污染物,空气过敏原和室内/职业暴露与过敏结膜炎联系起来.
- 评估环境因素对AC的发病,恶化和临床负担的贡献.
主要方法:
- 在PROSPERO.中注册的PRISMA 2020和AMSTAR-2指南的系统审查.
- 搜索了PubMed,科学网和Scopus;通过两个独立审稿人使用MINORS工具进行数据提取和质量评估.
- 由于29项纳入研究的实质性异质性,结果的叙述综合.
主要成果:
- 在空气污染物 (颗粒物,NOx,SO2,CO,O3) 与增加的交流频率/严重性之间发现了一致的关联.
- 在花粉和空气污染物之间观察到协同效应;室内暴露与儿童风险增加有关.
- 职业环境显示了暴露-反应关系;实验研究确定了诸如上皮质屏障破坏和NF-κB/TSLP信号传递等机制.
结论:
- 环境暴露显著导致过敏结膜炎的发展和恶化.
- 这些发现支持了改善预防策略和AC个性化临床管理的需要.
- 对特定暴露机制联系的进一步研究可以改进对眼睛表面炎症的干预措施.
相关概念视频
Allergic Reactions
32.7K
Overview
32.7K
Asthma-I: Introduction
3.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.6K
Asthma-II: Pathophysiology and Classification
4.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.7K
Asthma: Pathogenesis and Management
1.5K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.5K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
2.0K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
2.0K
Allergic Reactions: Anaphylaxis
77
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
77


