Search research articles

关于 JoVE

概览领导团队博客 JoVE 帮助中心

作者

出版流程编辑委员会范围与政策同行评审常见问题投稿

图书馆员

用户评价订阅访问资源图书馆顾问委员会常见问题

研究

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments 存档

教育

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual 教师资源中心教师网站

使用条款与条件

相关概念视频

Psychosis: Goals of Pharmacotherapy

Psychosis: Goals of Pharmacotherapy

Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序

Same author

Severe Ecthyma Gangrenosum in a Pediatric Patient With Neutropenia and a Novel HELLS Variant: Case Report.

Clinical case reports·2026

Same author

Successful azithromycin desensitization using a modified protocol after initial reaction: A pediatric case report.

IDCases·2026

Same author

Semaglutide in cognitive dysfunction: neuroprotective potential, clinical trial limitations, and a prevention-focused framework.

Frontiers in aging neuroscience·2026

Same author

Association between HbA1c and breast cancer risk in women with type 2 diabetes mellitus: A case-control study.

Medicine·2026

Same author

Acrylamide Exposure Exacerbates Type 2 Diabetes-Induced Neurotoxicity: An Integrated Neurobehavioral and Molecular Investigation.

Life (Basel, Switzerland)·2026

Same author

Timing of Allergenic Food Introduction in Infants, Saudi Arabia: A Cross-Sectional Study.

Nutrients·2026

Search research articles

相关实验视频

Updated: Feb 28, 2026

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

克洛扎通过调节胆能功能,氧化应激和老鼠的亡信号来缓解脂聚糖诱导的认知功能障碍.

Vasudevan Mani¹, Mohammed A Almatrafi¹

¹Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah 51452, Saudi Arabia.

Life (Basel, Switzerland)

|February 27, 2026

概括

克洛扎 (CLZ) 治疗在神经毒性大鼠模型中改善了认知功能. 通过调节参与认知和细胞存活的关键分子通路,CLZ表现出神经保护作用.

关键词:

灭症 (apoptosis) 是一种死亡的过程.克洛扎类药物克洛扎类药物认知功能认知功能脂多糖类糖化物 (Lipopolysaccharide) 是一种脂多糖的化合物.神经退行症的神经退行症氧化应激是一种氧化应激.

更多相关视频

Brain Ventricular Microinjections of Lipopolysaccharide into Larval Zebrafish to Assess Neuroinflammation and Neurotoxicity

Brain Ventricular Microinjections of Lipopolysaccharide into Larval Zebrafish to Assess Neuroinflammation and Neurotoxicity

Published on: August 23, 2022

Sub-acute Cerebral Microhemorrhages Induced by Lipopolysaccharide Injection in Rats

Sub-acute Cerebral Microhemorrhages Induced by Lipopolysaccharide Injection in Rats

Published on: October 17, 2018

相关实验视频

Last Updated: Feb 28, 2026

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

Brain Ventricular Microinjections of Lipopolysaccharide into Larval Zebrafish to Assess Neuroinflammation and Neurotoxicity

Brain Ventricular Microinjections of Lipopolysaccharide into Larval Zebrafish to Assess Neuroinflammation and Neurotoxicity

Published on: August 23, 2022

Sub-acute Cerebral Microhemorrhages Induced by Lipopolysaccharide Injection in Rats

Sub-acute Cerebral Microhemorrhages Induced by Lipopolysaccharide Injection in Rats

Published on: October 17, 2018

科学领域:

神经科学是一个神经科学.
药理学药理学是一个学科.
生物化学生物化学

背景情况:

克洛扎 (CLZ) 是一种用于治疗耐药精神分裂症的非典型抗精神病药物.
精神分裂症患者经常经历持续的认知障碍.
需要进一步阐明CLZ对认知和神经保护作用的机制.

研究的目的:

在大鼠中研究CLZ对脂聚糖 (LPS) 诱导的神经毒性的神经保护作用.
探索CLZ如何调节认知功能和相关的分子通路.

主要方法:

给大鼠施加LPS以诱导神经毒性,随后进行CLZ治疗.
用行为迷宫测试 (EPM,NOR,Y-迷宫) 评估认知功能.
分子分析包括胆固醇功能,神经退行性标志物,氧化应激和亡.

主要成果:

在行为测试中,CLZ治疗显著改善了认知表现.
CLZ增强了乙胆 (ACh) 水平,并提高了抗亡蛋白Bcl-2的调节.
CLZ减少了神经毒性标记物,包括GSK-3β活性,脂质过氧化 (LPO) 和亲亡蛋白 (Bax,c-Caspase-3),同时恢复了抗氧化防御 (catalase,GSH).

结论:

在LPS诱导的老鼠模型中,CLZ表现出神经保护作用,增强认知能力.
通过调节胆固醇传播,氧化应激和亡来调节CLZ的益处.
这些发现支持CLZ在改善精神分裂症认知缺陷方面的潜力.