选择性雌激素受体调节器在女性:我们知道什么,还有什么仍然缺失
Veselin Vasilev1, Katerina Georgieva1, Maria Kraeva2
1Department of Physiology, Medical Faculty, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.
Life (Basel, Switzerland)
|February 27, 2026
概括
选择性雄激素受体调节剂 (SARMs) 对女性来说是有前途的.
科学领域:
- 内分泌学和生殖科学 生殖科学
- 药理学 药理学 是一个学科.
- 在瘤学瘤学.
背景情况:
- 雄激素受体 (AR) 信号影响女性生理学,但与男性相比,研究不足.
- 选择性雄激素受体调节剂 (SARMs) 旨在产生具有较少副作用的组织选择性合成体效应.
- 对于女性的SARM的效果和安全性尚未得到充分证实.
研究的目的:
- 审查关于SARM在雌性动物和女性中使用的临床前和临床证据.
- 专注于AR生物学,组织选择性,治疗潜力和SARM在女性中的安全性.
- 识别知识缺口和需要进一步的性别特定研究.
主要方法:
- 来自PubMed,Scopus和Google Scholar的文献叙事审查. 这是一个很好的例子.
- 包括关于性别特异性AR信号和SARM效应的实验和临床研究.
- 在女性模型和人类受试者中对SARM结果的综合数据.
主要成果:
- 临床前研究表明,SARM可以改善女性模型的肌肉,骨和性动机.
- 绝经后妇女的临床研究表明,瘦身量增加,具有有限的雄激素作用.
- 报告的副作用包括不一致的功能益处,脂质变化和肝酶升高.
- 针对AR的SARM在特定的乳腺癌类型中表现出潜在的抗瘤活性.
结论:
- 在女性的各种疾病中,SARM具有治疗潜力,包括肌肉消耗和某些癌症.
- 在女性中,SARM的长期安全性和有效性需要进一步进行全面的研究.
- 性别特定的临床试验对于充分描述女性人口中SARM的益处和风险至关重要.
相关概念视频
01:31Transducer Mechanism: Nuclear Receptors
3.7K
Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
3.7K
01:22Hormonal Regulation of the Menstrual Cycle
1.9K
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
1.9K
01:17Adrenergic Antagonists: Chemistry and Classification of ɑ-Receptor Blockers
1.8K
Adrenergic antagonists, or sympatholytics, inhibit adrenoceptor activation driven by catecholamines or agonists. Based on their adrenoceptor specificity, adrenergic blockers can be categorized into two primary groups: α-adrenergic blockers (α-blockers) and β-adrenergic blockers (β-blockers). α-blockers interact with α1 and α2 subtypes of α-adrenoceptors.
Nonselective α-blockers: Nonselective α-blockers contain haloalkylamine or imidazoline...
Nonselective α-blockers: Nonselective α-blockers contain haloalkylamine or imidazoline...
1.8K
01:30Hormonal Control of the Ovarian Cycle
7.2K
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
7.2K
01:28Structure-Activity Relationships and Drug Design
1.9K
Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
1.9K
01:26Testosterone: Functions and Regulation
2.5K
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
2.5K