在多发性硬化症中,光学连贯性断层扫描血管造影衍生的周周血管密度发现
Angeliki G Filippatou1, Vasilios S Liarakos2, Eirini Okoutsidou3
1Second Department of Neurology, "Attikon" University Hospital, School of Medicine, National and Kapodistrian University of Athens, 124 62 Athens, Greece.
Journal of clinical medicine
|February 27, 2026
概括
多发性硬化症 (MS) 视神经炎 (ON) 导致周周神经纤维层变薄,主要在象限. 光学连贯断层扫描血管造影 (OCTA) 显示MS中周周血管密度 (VD) 降低,也有利于象限.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 与多发性硬化症 (MS) 相关的视神经炎 (ON) 会导致周周神经纤维层 (pRNFL) 变薄,通常会影响象限.
- 光学连贯断层扫描血管造影 (OCTA) 可视化视网膜血管结构,提供有关MS的血管变化的见解.
- 之前的研究表明,MS患者的周囊血管密度 (VD) 降低,但对象限特定的模式不太了解.
研究的目的:
- 通过使用OCTA,研究患有多发性硬化症 (MS) 的患者周周血管密度 (VD) 减少的模式.
- 为了确定VD损失在周围皮囊区域是否在MS患者中遵循特定的象限模式.
主要方法:
- 光盘OCTA扫描在MS患者 (PwMS) 和健康对照者 (HC) 上进行.
- 周周血管密度 (VD) 为整体区域和个别象限计算.
- 眼睛最近的ON (在六个月内) 被排除在分析之外.
主要成果:
- 与HC相比,在具有ON的MS眼睛中,周周垂体VD较低,时间象限的减少最为显著.
- 没有最近的ON的MS眼睛仅在象限中显示出明显较低的VD,与HC相比.
- 在相应的视网膜区域中,在OCT和OCTA指标之间发现了强烈的相关性.
结论:
- 在MS中视网膜血管变化,特别是视神经炎后,可能主要影响象限.
- 需要对更大的队列进行进一步的研究,以充分了解MS中周周血管损伤的模式和进展.
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