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慢性脏病患者的肌肉强度和左心室缩和腹缩功能障碍 男人:试点研究
Katarzyna Romejko1, Katarzyna Szamotulska2, Stanisław Niemczyk1
1Department of Internal Diseases, Nephrology and Dialysis, Military Institute of Medicine-National Research Institute, 128 Szaserów Street, 04-141 Warsaw, Poland.
Journal of clinical medicine
|February 27, 2026
概括
在晚期慢性病 (CKD) 患者中,手握强度和五次坐立测试不是肌肉强度的等效衡量. 坐立测试可以更好地预测这些患者的透缩功能障碍.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 心脏病学 心脏病学
- 老年病的医生 老年病的医生
背景情况:
- 标志着肌肉强度和质量减少的萨尔科佩尼亚与心力衰竭与保留射出分数 (HFpEF) 有关.
- 左心室扩张性功能障碍 (LVDd) 是HFpEF的主要驱动因素,影响心脏功能.
- 慢性病 (CKD) G4-G5阶段,不接受透析,代表患有缩症和心脏功能障碍的风险人口.
研究的目的:
- 调查肌肉强度评估与非透析CKD患者LVDd的心声学参数之间的关系.
- 为了确定手握强度 (HGS) 和五次坐立测试 (FTSST) 是否相当于反映这个队列中的心脏状况.
主要方法:
- 招募了46名不接受透析的CKD阶段G4-G5的男性,除以HGS (<27公斤对≥27公斤).
- 使用HGS和FTSST.ST评估肌肉力量.
- 进行跨胸腔心声扫描,以评估LVDd和缩功能参数 (例如,隔膜e',E/e',LVEF,TAPSE).
主要成果:
- 上肢和下肢肌肉强度评估 (HGS和FTSST) 在CKD患者中没有相关性.
- 长时间的FTSST与扩张功能受损相关 (下隔膜e',高E/e').
- 患有长期FTSST的患者表现出左心室喷射分数 (LVEF) 和三环状平面缩外流 (TAPSE) 的减少.
结论:
- 在非透析CKD患者的肌肉力量评估中,HGS和FTSST是不可互换的.
- 肌肉强度下降,特别是在FTSST上显示,与此群体中的LVDd有关.
- 在晚期CKD中,FTSST比HGS更敏感地预测LVDd和心功能障碍.
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