抑郁症症状,功能状态和心血管参数在患有严重抑郁症的患者接受心脏康复治疗,同时接受西治疗:一个前性观察性研究
Iván Hoditx Martín-Costa1,2, Rafael Colman1, Álvaro García-Amador1
1Clínica Colman Especialidades Médicas, 11008 Cádiz, Spain.
Journal of clinical medicine
|February 27, 2026
概括
在重度抑郁症患者的心脏康复中使用西,在12周内改善了抑郁症状和功能状态. 实际数据显示VO2max和体重的积极变化,副作用很少.
科学领域:
- 心脏病学 心脏病学
- 精神病学是一个精神病学.
- 康复医学 康复医学 康复医学
背景情况:
- 有限的现实世界数据存在于西西丁在心脏康复 (CR) 中用于严重抑郁症 (MDD).
- 了解西对这种人群中抑郁症状和功能状况的影响至关重要.
- 需要评估心血管和生物识别变化以及心理结果.
研究的目的:
- 描述抑郁症状,功能状态和心血管/生物识别参数的变化.
- 为了评估vortioxetine在接受CR的MDD患者的现实世界中的有效性.
- 为未来的受控试验生成假设.
主要方法:
- 展望性,12周的观察性研究.
- 包括49名接受CR并接受西的MDD患者.
- 在基线和第3,7,12周评估汉密尔顿抑郁评分表 (HAM-D) 和希恩残疾评分表 (SDS);在基线和第12周测量心血管和生物识别参数.
主要成果:
- 在12周内,HAM-D和SDS得分显著下降 (p < 0.001).
- 观察到VO2max,体重,BMI和腰围的改善 (p <0.05).
- 喷射分数,血压或QTc间隔没有显著变化;6.1%的轻微不良反应.
结论:
- 在CR期间对MDD患者进行的沃尔提奥塞丁治疗显示,心理和功能指标的纵向变化是积极的.
- 现实世界的数据突出显示了综合康复环境中的临床轨迹.
- 结果为未来的研究提供了产生假设的证据.
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