长期结果的基于性别的差异 经过慢性全闭症的皮肤冠状动脉干预后的长期结果
Ignacio Gallo1,2,3,4, Rafael Gonzalez-Manzanares1,2,3,4, Luis Carlos Maestre-Luque1,2
1Department of Cardiology, Reina Sofia University Hospital, 14002 Córdoba, Spain.
Journal of clinical medicine
|February 27, 2026
概括
慢性通皮冠状动脉干预 (CTO-PCI) 中基于性别的差异显示了类似的整体结果,但女性心肌梗塞 (MI) 的风险更高. 长期来看,CTO-PCI对两性同样安全有效.
科学领域:
- 心脏病学 心脏病学
- 干预心脏病学 干预心脏病学
- 健康 结果 研究 研究 结果
背景情况:
- 对于慢性全闭症 (CTO) 经皮穿透冠状动脉干预 (PCI) 后的临床结果的性别差异尚不清楚.
- 根据性别分层的CTO-PCI后长期结果的现实世界数据有限.
研究的目的:
- 调查CTO-PCI后性别和长期临床结果之间的关联.
- 为了比较CTO-PCI在男性和女性中的安全性和有效性.
主要方法:
- 对928名接受CTO-PCI (2011-2024) 的患者进行了回顾性分析.
- 主要终点:在6年随访期间发生重大心脏不良事件 (MACE).
- 用于控制基线差异的IPTW调整的考克斯回归.
主要成果:
- 女性年龄较大,糖尿病和高血压的发病率较高,但血管学复杂性较低.
- 技术和程序的成功率在两性之间是可比的.
- 在女性中,未调整的MACE率较高,但调整后的分析显示,整体MACE没有显著差异. 然而,女性在手术后心肌梗塞 (MI) 的风险明显更高.
结论:
- 关于整体长期MACE,CTO-PCI在女性和男性的安全性和有效性相似.
- 尽管总体调整的MACE相似,但接受CTO-PCI的女性面临着显著更高的心肌梗塞风险.
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