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相关概念视频

The Oral Microbiota01:27

The Oral Microbiota

The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
Development of the Oral Microbiota01:28

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...

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In Situ Detection of Bacteria within Paraffin-embedded Tissues Using a Digoxin-labeled DNA Probe Targeting 16S rRNA
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唾液Sirtuin-1水平与牙周炎之间的关联

Leonardo Lorente1, Esther Hernández Marrero2, Pedro Abreu González3

  • 1Intensive Care Unit, Hospital Universitario de Canarias, Ofra s/n, 38320 San Cristóbal de La Laguna, Tenerife, Spain.

Journal of clinical medicine
|February 27, 2026
PubMed
概括

低的唾液Sirtuin-1 (SIRT-1) 度可能表明牙周炎. 这项研究在牙周炎患者中发现了较低的SIRT-1水平,这表明牙周炎在诊断中可能发挥作用,尽管需要进一步研究.

关键词:
氧化过程中的氧化.牙周炎是指牙周炎的一种疾病.唾液系统 唾液系统斯尔图因-1 斯尔图因-1

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科学领域:

  • 生物化学 生物化学
  • 口腔健康 口腔健康
  • 衰老研究研究 衰老研究

背景情况:

  • 赛尔图因-1 (SIRT-1) 是一种具有抗氧化,抗炎和抗丧性能的酶,影响衰老和与年龄相关的疾病.
  • 之前对牙周炎的唾液SIRT-1的研究受限于小样本大小,没有发现显著差异.
  • 这项研究通过在更大的队列中调查唾液SIRT-1来弥补这一差距.

研究的目的:

  • 为了比较牙周炎患者和健康受试者之间的唾液SIRT-1度.
  • 为了确定唾液SIRT-1水平和牙周炎之间的关联.
  • 评估唾液SIRT-1对牙周炎的诊断潜力.

主要方法:

  • 一项涉及144名参与者的横截面研究 (59名患有牙周炎,85名没有牙周炎).
  • 测量了唾液中的SIRT-1度.
  • 采用多变量逻辑回归和接收器操作特征 (ROC) 分析.

主要成果:

  • 唾液中SIRT-1度低 (<1.2 ng/mL) 独立地与牙周炎相关 (OR = 2.84,p = 0.04).
  • 在ROC分析中,牙周炎的诊断能力为74% (p < 0.001).
  • 这项研究包括迄今为止在牙周炎患者的唾液SIRT-1中最大的样本规模.

结论:

  • 唾液中SIRT-1度较低可能与牙周炎存在有关.
  • 唾液SIRT-1显示出作为牙周炎辅助诊断标记物的潜力.
  • 由于研究的局限性,需要进一步的研究来验证这些初步发现.