神经病痛,疼痛强度和类风湿性关节炎炎炎症活动之间的关联
Zeynel Abidin Akar1, Dilan Yıldırım1, Ömer Karakoyun2
1Division of Rheumatology, Department of Physical Therapy and Rehabilitation, Faculty of Medicine, Dicle University, 21300 Diyarbakır, Türkiye.
Journal of clinical medicine
|February 27, 2026
概括
在类风湿性关节炎 (RA) 中,诺西普拉斯样疼痛特征很常见,影响22.5%的患者. 这些特征与疼痛强度和心理社会因素有关,而不仅仅是炎症,突出了全面疼痛管理策略的需要.
科学领域:
- 类风湿病学 类风湿病学
- 疼痛医学 医学 疼痛医学
- 临床心理学 临床心理学
背景情况:
- 以改变疼痛处理为特征的nociplastic疼痛显著影响类风湿性关节炎 (RA) 患者.
- 了解RA中类似于nociplastic的疼痛的临床相关性和疾病活动关联是至关重要的,但仍然不完整.
研究的目的:
- 为了确定RA患者中类似于nociplastic的疼痛特征的患病率.
- 研究这些疼痛特征与疾病活动,疼痛强度,疲劳,睡眠质量和与健康相关的生活质量之间的关联.
主要方法:
- 一项涉及160名RA患者的横截面研究.
- 通过PainDETECT问卷进行评估的诺西普拉斯样疼痛.
- 评估了疾病活动 (DAS28),疼痛 (VAS),疲劳 (FACIT-F),睡眠 (PSQI) 和生活质量 (SF-36).
主要成果:
- 22.5%的RA患者表现出类似于nociplastic的疼痛特征.
- 这些患者报告了更高的疼痛强度,疲劳,睡眠不佳和生活质量低下.
- 疼痛检测得分与疼痛强度有很强的相关性,与DAS28有中度的相关性,但回归分析确定疼痛强度,疼痛关节数和教育是独立的预测因素,不包括炎症标志物.
结论:
- 诺西普拉斯样疼痛在RA中很普遍,并且与疼痛强度,关节疼痛和心理社会因素相关,独立于炎症标志物.
- 常规评估nociplastic-like疼痛对于个性化的RA疼痛管理至关重要.
- 在RA护理中,应考虑与抗炎治疗一起考虑中央敏感化机制.
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