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在iStent Infinite®植入后持续的眼内压力控制用于类固醇诱导的玻璃眼瘤:一个案例报告
Kyunghee Lee1,2, Je Hyun Seo3, Leslie Jay Katz4
1Division of Nephrology, Hypertension and Kidney Transplantation, University of California, Irvine, CA 92868, USA.
Journal of clinical medicine
|February 27, 2026
概括
从静脉内Ozurdex植入物中产生的类固醇诱导的玻璃眼 (SIG) 可以通过微创性玻璃眼手术来管理. 在需要持续类固醇治疗的患者中,三重带微型旁路支架安全控制了眼内压力.
科学领域:
- 眼科医生 眼科 眼科
- 玻璃眼研究研究 玻璃眼研究
- 手术创新 在外科创新.
背景情况:
- 类固醇诱导的玻璃眼 (SIG) 是使用皮质类固醇的已知并发症,特别是静脉内德克萨米他植入物.
- 在SIG中,眼内压力升高 (IOP) 是由于状眼网的功能障碍和水性外流阻力增加造成的.
- 虽然医疗管理是常见的,但由于持续的内压升高,一些SIG病例需要手术干预.
研究的目的:
- 报告第一个成功管理与Ozurdex相关的类固醇诱导青光瘤的案例,使用微创性青光瘤手术 (MIGS).
- 为了评估三重带微型旁路支架 (iStent无限) 的安全性和有效性,在患有因SIG而持续升高IOP的患者中.
- 探索MIGS在需要持续静脉内类固醇治疗的患者中的潜在作用.
主要方法:
- 一名73岁的男性患有耐火性黄斑胀,接受了视内Ozurdex植入物,随后发生严重的IOP升高.
- 最大局部药物治疗未能控制IOP,观察到视野进展和视网膜神经纤维层变薄.
- 在正在进行的类固醇治疗和患者在局部滴滴方面遇到困难的情况下,植入了三个iStent无限带微型旁路支架来管理IOP.
主要成果:
- 通过iStent无限植入,术后内血压从34mmHg显著降低到13mmHg.
- 在植入后的12个月内,内腔压力保持稳定,平均为15mmHg.
- 随着Ozurdex治疗的继续,黄斑胀得到了有效的管理,并且在手术后没有观察到显著的IOP峰值.
结论:
- 在这种情况下,三重带微绕道支架为类固醇诱导的玻璃眼提供了安全和持续的IOP控制.
- 无限植入的iStent是一种可行的手术选择,用于在需要持续服用静脉内类固醇的患者中管理SIG.
- 这一案例凸显了MIGS作为治疗眼球类固醇使用相关的复杂绿眼病病例的有效治疗潜力.
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