全免疫炎症值 (PIV) 和HALP评分作为急性冠状动脉综合征患者的独立预后指标
Azmi Eyiol1, Hatice Eyiol2, Ahmet Yilmaz3
1Department of Cardiology, Beyhekim Training and Research Hospital, 42100 Konya, Turkey.
Journal of clinical medicine
|February 27, 2026
概括
新的生物标志物,泛免疫炎症值 (PIV) 和血红蛋白-白蛋白-淋巴细胞-血小板 (HALP) 评分,可以预测急性冠状动脉综合征 (ACS) 患者的死亡率. 与PIV相比,HALP得分显示出更高的预测能力.
科学领域:
- 心脏病学 心脏病学
- 生物标志物 生物标志物
- 内部医学 内部医学
背景情况:
- 急性冠状动脉综合征 (ACS) 是全球主要的死亡原因.
- 新的炎症和营养生物标志物可能会改善ACS的风险分层.
- 全免疫炎症值 (PIV) 和血红蛋白-白蛋白-淋巴细胞-血小板 (HALP) 评分是潜在的预后指标.
研究的目的:
- 在ACS患者中评估PIV和HALP得分的预后值.
- 为了确定这些得分是否可以独立预测死亡率.
- 为了比较PIV和HALP得分的预测性能.
主要方法:
- 对1134名ACS患者进行了回顾性多中心研究.
- 计算PIV (中性粒细胞 × 血小板 × 单细胞/淋巴细胞).
- 计算HALP得分 (血红蛋白 × 白蛋白 × 淋巴细胞/血小板).
- 分析与临床参数的相关性和使用ROC分析预测死亡率.
主要成果:
- PIV与WBC,热素和CRP正相关;与HDL和射出分数负相关.
- PIV独立预测的死亡率 (AUC = 0.619).
- HALP得分与年龄,热素,CRP和ICU住院以及独立预测的死亡率负相关 (AUC = 0.722).
- 与PIV相比,HALP得分显示出更好的死亡率预测.
结论:
- 在ACS中,PIV和HALP得分是独立的预后标志物.
- 这些分数反映了炎症负担和营养状况.
- 整合PIV和HALP得分可能会提高高风险ACS患者的风险分层和个性化管理.
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