在自闭症谱系障碍中的肠道微生物群-基-大脑轴:益生菌干预的新前沿
Yi Cheng1,2,3, Liangyu Zhang1,2,3, Yalin Li1,2,3
1Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, China.
Microorganisms
|February 27, 2026
概括
(Trp) 代谢异常和肠道失调与自闭症谱系障碍 (ASD) 有关. 特定的益生菌通过调节肠-大脑轴和Trp代谢,显示出缓解ASD症状的潜力.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 代谢途径 代谢途径
背景情况:
- 托 (Trp) 的新陈代谢影响神经功能,免疫反应和肠道平衡.
- 自闭症谱系障碍 (ASD) 与Trp代谢障碍和肠道微生物群失调有关.
- 肠道失生症可以引发炎症,并通过kynurenine路径 (KP) 改变Trp代谢,影响肠道-大脑轴.
研究的目的:
- 探索自闭症谱系障碍 (ASD) 与肠道微生物群-Trp-大脑轴之间的关系.
- 审查Trp代谢异常在ASD病变发生中的作用.
- 要总结益生菌在ASD中的治疗潜力.
主要方法:
- 临床前和临床研究的文献综述.
- 在ASD中分析肠道微生物群-Trp-大脑轴.
- 针对Trp代谢的益生菌干预措施的评估.
主要成果:
- 自闭症患者表现出Trp代谢障碍和肠道失调.
- 肠道微生物群失生症激活了胺二二氧化酶1 (IDO1),增加了Trp进入KP.
- 这一途径有助于神经炎症,血清激素失衡,以及ASD中肠道屏障功能受损.
- 特定的益生菌 (例如,乳杆菌,Bifidobacterium) 可能通过调节肠道微生物群-Trp轴来缓解ASD症状.
结论:
- 托芬代谢在ASD中起着至关重要的作用.
- 益生菌通过向Trp代谢途径,代表了ASD的潜在辅助疗法.
- 需要进一步的研究来澄清分子机制,并确保益生菌干预的长期安全性.
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