新型皮肤和口服衍生益生菌候选者:功能评估和应用前景
Ivana Repić1, Nina Čuljak1, Matea Hrupački1
1Laboratory for General Microbiology and Food Microbiology, University of Zagreb Faculty of Food Technology and Biotechnology, Pierottijeva 6, 10000 Zagreb, Croatia.
Microorganisms
|February 27, 2026
概括
这项研究确定了皮肤和唾液中的潜在益生菌和酵母. 乳酸菌 rhamnosus S3 显示出高益生菌潜力,而 Limosilactobacillus sp. 显示出高益生菌潜力. S1适用于局部应用.
科学领域:
- 微生物学 微生物学
- 益生菌 益生菌 益生菌
- 皮肤和口腔微生物组
背景情况:
- 皮肤和口腔环境拥有多样化的微生物群落,具有潜在的健康益处.
- 这些非胃肠道 (GIT) 微生物可能具有超越传统肠道益生菌的特性.
研究的目的:
- 从人类的唾液和皮肤中识别和功能性地表征细菌和酵母分离物.
- 评估它们作为肠道和局部应用的益生菌的潜力.
主要方法:
- 来自唾液和皮肤的分离物被使用API和MALDI-TOF质谱学识别.
- 评估的功能性质包括抗微生物活性,自身聚合,抗氧化能力,耐冷干燥性和细胞粘附性.
主要成果:
- Lacticaseibacillus rhamnosus S3表现出显著的益生菌潜力,包括对黄金葡萄球菌的抗菌活性和对模拟的GIT条件的耐受性.
- 利莫西拉科巴西勒斯种类 (Limosilactobacillus sp. S1对Cutibacterium acnes表现出强烈的抗菌活性,并且对HaCaT细胞具有很高的粘附性,这表明皮肤病学用途.
- 细菌菌素 (Saccharomyces cerevisiae) 的分离物表现出良好的自身聚合和抗氧化能力,但抗冷干燥性较差.
结论:
- 乳酸酶ibacillus rhamnosus S3是益生菌开发的一个有前途的候选人.
- 利莫西拉科巴西勒斯种类 (Limosilactobacillus sp. S1具有局部皮肤学应用的潜力.
- 单独的Saccharomyces cerevisiae可能在益生菌配方中存在局限性,因为其冷干燥稳定性较低.
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