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用于预防和诊断酒精性肝病的微生物生物标志物

Goo Hyun Kwon¹, Hyunjoon Park¹, Hyeong Seop Kim¹

¹Institute for Liver and Digestive Diseases, Hallym University, Chuncheon 24252, Republic of Korea.

|February 27, 2026

概括

某些肠道细菌在治疗与酒精相关的肝病 (ALD) 方面表现有前途. 乳杆菌种类改善了症状,而血液中的Veillonella dispar可能有助于诊断ALD.

科学领域:

微生物学微生物学
肝病学肝病学是一种肝病学.
胃肠病学胃肠病学

背景情况:

肠道微生物群的改变与酒精相关性肝病 (ALD) 的进展有关.
识别具有治疗或诊断潜力的特定微生物对于ALD管理至关重要.

研究的目的:

为了识别与ALD相关的细菌菌株,用于治疗或诊断应用.
在小鼠模型中评估特定细菌菌株对ALD的影响.
评估血液中的细菌DNA水平对ALD的诊断效用.

主要方法:

查人类便样本的候选微生物.
在已建立的酒精相关肝病小鼠模型中评估微生物影响.
在血液样本中的细菌DNA量化用于诊断评估.

主要成果:

在ALD模型中,用*Lactobacillus helveticus*和*Lactobacillus lactis*治疗改善了肠道失调,肝炎和内毒性.
*Veillonella dispar*,在ALD患者中发现富含,在体内没有显示治疗益处.
*V. dispar* 血液丰度显示出诊断能力,区分ALD患者与控制组,AUC为0.815.

结论:

*Lactobacillus helveticus*和*Lactobacillus lactis*显示出作为ALD治疗益生菌的潜力.
*Veillonella dispar*可以作为ALD诊断的非侵入性生物标志物.
针对微生物群的策略为ALD预防和诊断提供了一个新的途径.

关键词:

与酒精相关的肝脏疾病生物标志物生物标志物我们的肠道微生物群.这是一种炎症炎症炎症炎症.

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