用于口腔输送大麻素 (CBD) 的溶解微针的开发和描述
Eleni Paganopoulou1, Emmanouil Tzimtzimis2, Dimitrios Tzetzis2
1Department of Pharmacy, Division of Pharmaceutical Technology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Micromachines
|February 27, 2026
概括
这项研究开发了溶解微针,用于口腔输送大麻素 (CBD),为患者提供了口服的友好的替代方案. 微针有效地将CBD输送到口腔组织,绕过第一通代谢.
科学领域:
- 制药科学 制药科学
- 生物材料工程 生物材料工程
- 药物输送系统 药物输送系统
背景情况:
- 大麻素 (CBD) 具有抗炎和抗焦虑的特性,但口服药物面临诸如第一通代谢等挑战.
- 微针 (MN) 技术提供了通过粘膜组织增强药物吸收的潜力.
- 目前的MN制造方法,如微型成型,在定制针的几何学方面存在局限性.
研究的目的:
- 开发和评估可溶解的微针,用于口腔输送大麻素 (CBD).
- 利用增材制造,特别是数字光处理 (DLP) 打印,用于定制的微针模具制造.
- 评估在猪口粘膜中含有CBD的微针的生理化学,机械和体外/体外性能.
主要方法:
- 使用数字光处理 (DLP) 3D打印制造微针模具.
- 使用Eudragit L100-55和Eudragit RSPO通过反向成型生产溶解的聚合物微针.
- 评估微针的特性,包括插入猪口腔粘膜,药物释放动力学,以及组织完整性的组织学评估.
主要成果:
- 通过使用DLP打印成功制造定制的微针模具和溶解微针.
- 证明有效地将微针插入口腔组织,并控制活性药物成分 (API) 的释放.
- 同焦点显微镜和组织学评估证实了微针的功能和对粘膜完整性的最小影响.
结论:
- 使用DLP打印模具制造的溶解微针为口腔大麻素 (CBD) 输送提供了一个有效的平台.
- 这种方法提供了一个有前途的,患者友好的替代口服CBD管理,通过绕过第一通代谢.
- 该研究强调了增材制造在创建先进的药物输送系统以提高治疗结果方面的潜力.
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