相关实验视频
Updated: Feb 28, 2026

09:07
Murine Model of Epicutaneously-Induced Immunomodulation
Published on: June 24, 2025
598
肠道微生物组在IgE介导的食物过敏患者-一个叙述审查
Neel Singh1,2, Erin Hosein3, Yamini V Virkud1,4,5
1Department of Pediatrics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Nutrients
|February 27, 2026
概括
食物过敏 (FA) 是一个重要的健康问题. 新兴的基于微生物组的策略,如益生菌和便微生物群移植 (FMT),显示出对管理FA的承诺,补充现有疗法.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 微生物学 微生物学
背景情况:
- 食物过敏 (FA) 是一个重大的公共卫生挑战,影响儿童和成人人口.
- 免疫球蛋白E (IgE) 介导的FA涉及特定IgE引发的过敏反应,导致巨细胞和基细胞脱粒.
- 目前的管理策略包括避免过敏原,口腔免疫疗法 (OIT),下语言免疫疗法 (SLIT) 和奥马利祖马布,尽管这些并没有治愈作用.
研究的目的:
- 审查肠道微生物组在口服耐受性对食品抗原的发展和调节中的作用.
- 探索益生菌,便微生物群移植 (FMT) 和饮食干预措施的潜力,以管理已建立的FA.
- 检查微生物组与OIT之间的相互作用,并确定临床实施的障碍.
主要方法:
- 这篇叙述性综述综合了目前关于针对食物过敏的基于微生物组的干预措施的研究.
- 它研究了益生菌,FMT和饮食变化可能影响FA的机制.
- 该审查还讨论了肠道微生物组与OIT疗效之间的相互作用.
主要成果:
- 肠道微生物组在口服耐受性对食物抗原方面发挥着至关重要的作用.
- 益生菌,FMT和饮食修改正在成为FA的潜在治疗策略.
- 微生物组与OIT之间的相互作用需要进一步研究.
结论:
- 未来的研究应该研究超越OIT的微生物组与免疫疗法的相互作用.
- 便微生物种移植 (FMT) 显示出作为已确定的食物过敏的辅助疗法的潜力.
- 开发基于微生物组的治疗方法的标准化方案和终点对于临床翻译至关重要.
相关概念视频
Irritable Bowel Syndrome I: Introduction
1.3K
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
1.3K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
972
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
972
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
2.0K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
2.0K
What is Monogastric Digestion?
76.4K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
76.4K
Allergic Reactions
32.7K
Overview
32.7K
Allergic Reactions: Anaphylaxis
77
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
77

