维生素D 充足度审查:证据表明,患MASLD的成年人处于风险中的剂量反应效应
Gediz Dogay Us1,2,3, Francesco Innocenti4, Ozgur Muhammet Koc5
1School of Nutrition and Translational Research in Metabolism, Maastricht University, 6211 LK Maastricht, The Netherlands.
Nutrients
|February 27, 2026
概括
较高的维生素D水平与高危成年人代谢功能障碍相关的脂肪性肝病 (MASLD) 的几率降低有关. 这表明维生素D可能是预防和管理MASLD的可修改因素.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 维生素D对肝脏健康至关重要,它影响了代谢功能障碍相关的乳脂性肝病 (MASLD) 的乳脂性肝病和纤维化.
- 在MASLD中,为肝脏提供保护的最佳血清维生素D水平尚未确定.
研究的目的:
- 调查维生素D状态与MASLD之间的关联.
- 为了确定更高的维生素D度是否能提供超出已确定的足够水平的保护.
主要方法:
- 对1039名患有心脏代谢风险因素的成年人进行了多中心横截面研究.
- 排除过度饮酒或其他肝脏疾病病因的参与者.
- 评估MASLD和显著纤维化,使用振动控制的短暂弹性学;测量维生素D水平,足够性定义为≥20 ng/mL.
主要成果:
- 维生素D的不足与MASLD和显著纤维化的原始几率较低有关.
- 调整后的分析显示,维生素D的充足量对于MASLD没有统计学意义 (aOR=0.60,p=0.06),但对纤维化有意义 (aOR=0.48,p=0.03).
- 在调整的模型中,最高维生素D四分位数 (≥44 ng/dL) 与最低四分位数 (≤22 ng/mL) 相比,MASLD的几率降低了61%.
结论:
- 维生素D水平表明,在风险人群中,MASLD的几率有剂量依赖的降低.
- 虽然对纤维化的保护作用并不依赖于剂量,但维生素D成为预防MASLD的潜在可修改因素.
- 对维生素D在MASLD管理中的作用进行进一步的研究是有必要的.
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