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多和神经退行性疾病:知识挖掘洞察力,机械证据和新兴的营养应用

Xiaomei Wang¹, Huimin Zhao¹, Jiao Yang¹

¹Institute of Agricultural Information, Chinese Academy of Agricultural Sciences, Beijing 100081, China.

|February 27, 2026

概括

聚醇在神经退行性疾病 (NDD) 中显示出多目标的神经保护潜力. 需要进一步的大型标准化临床试验来证实其在NDD预防和管理方面的有效性.

科学领域:

营养神经科学营养神经科学
药理学药理学是指药理学的学科.
生物化学生物化学

背景情况:

植物衍生化合物聚醇正在研究用于神经退行性疾病 (NDD) 管理.
研究涵盖了12个多类和7个主要的NDD,在2000年后出版的数量大幅增长.

研究的目的:

绘制NDD中多的研究格局和新兴主题的地图.
综合机制学证据,将临床前发现与临床结果联系起来.

主要方法:

从1940年到2024年,对主要数据库 (PubMed,Embase,Cochrane,Web of Science) 的综合图书统计和机制范围审查.
关键词的同时出现,聚类,以及BERTopic对景观分析的建模.
在关键途径中综合证据:氧化应激,神经炎症,蛋白质稳定,线粒体功能障碍和胆固醇调节.

主要成果:

确定了四个研究热点:抗氧化/神经保护作用,抗炎/信号,认知/衰老/性别特异性反应和动物模型.
关键干预措施包括表甲基酸盐,银杏,橄/可可多和黄化合物混合物.
有限的生物可用性和试验异质性影响临床效果估计.

结论:

聚醇具有针对NDD的多目标神经保护潜力.
传递系统和精密营养的进步可能会提高翻译.
较大的标准化临床试验对于NDD的基于证据的营养策略至关重要.

关键词:

热点是热点的热点.知识挖掘知识挖掘这些机制的机制.神经退行性疾病的神经退行性疾病聚醇是一种多醇.

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