补充剂的不同肝脏线粒体和炎症影响
Tyson J Morris1, Madeline D Morris2, Andrew J Parker2
1Department of Hematology and Oncology, Creighton University School of Medicine, Phoenix, AZ 85012, USA.
补充剂D-和L-β-基酸盐 (BHB) 显示出积极或惰性的肝功能. 相比之下,1,3-butanediol (BD) 则会引起严重的肝脏压力,影响ATP,线粒体和炎症.
科学领域:
- 生物化学 生物化学
- 代谢健康 代谢健康
- 营养科学 营养科学
背景情况:
- β-基酸盐 (BHB) 存在于具有明显生物活性的D-和L-反体.
- D-BHB是内源的形式;L-BHB是常见的种族补充剂.
- 1,3-butanediol (BD) 是一种基前体,安全性数据有限.
研究的目的:
- 在小鼠中研究D-BHB,L-BHB和BD对肝脏的急性和短期影响.
- 为了比较不同补充剂配方的安全性和有效性.
- 了解BHB和BD对肝脏代谢的不同影响.
主要方法:
- 在雄性C57BL/6小鼠中进行了急性 (2小时) 和短期 (8天) 测量试验.
- 评估了肝脏ATP,脂质过氧化 (MDA),线粒体功能 (氧气消耗,复合II,SDH),甘油三和炎症标志物 (IL-1β,TNF-α,CRP).
- 将D-BHB,L-BHB和BD与车辆控制器进行比较.
主要成果:
- 急性D-BHB和L-BHB增加了肝脏ATP; BD导致持续的ATP耗尽和氧化应激.
- 短期BD管理显著损害了线粒体复合II呼吸和增加肝脏甘油三.
- BD提高了所有测量的炎症标志物,而BHB反体保持了控制水平.
结论:
- D-BHB和L-BHB反体显示出安全或有益的肝功能.
- 1,3-butanediol (BD) 诱导严重的肝应激,氧化损伤和炎症.
- 这些发现支持BHB反体的治疗潜力,并警告不要在补充剂中使用BD.
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