维生素D的度是否重要? 血清维生素D度和补充剂对儿科骨折风险的后果影响
Tan Si Heng Sharon1, Eunice Anastasia Wilianto2, Andrew Kean Seng Lim1
1Division of Paediatric Orthopaedic Surgery, Department of Orthopaedic Surgery, National University Hospital, Singapore 119074, Singapore.
Nutrients
|February 27, 2026
概括
儿童维生素D水平较低与骨折风险增加有关. 优化维生素D状态可能会改善儿科骨健康并减少骨折.
科学领域:
- 儿童骨健康 儿童骨健康
- 营养生物化学 营养生物化学
- 流行病学 流行病学
背景情况:
- 维生素D和儿科骨折之间的关系是有争议的.
- 现有研究显示,有关维生素D状态和骨折风险的研究结果不一致.
研究的目的:
- 为了研究血清25(OH) D水平和骨折风险在一个大型东南亚儿科队列之间的关联.
- 评估维生素D充足,不足,缺乏和补充对儿科骨折风险的影响.
主要方法:
- 对18岁以下儿童进行回顾性横截面研究,测量血清25(OH) D.
- 统计分析包括单向ANOVA和Chi-square测试,以比较骨折和非骨折组.
- 维生素D状态类别和补充剂的患病率与骨折风险相关评估.
主要成果:
- 与对照人群相比,骨折儿童的血清中平均25(OH) D度较低.
- 低于最佳的,不足的和缺乏维生素D的水平与骨折风险的增加显著相关.
- 发现了维生素D补充剂与骨折风险之间的关联,但无法确定因果关系.
结论:
- 较高的血清25(OH) D度与儿童骨折风险降低相关.
- 优化维生素D状态 (血清25(OH) D>30 ng/mL) 可能是儿童骨健康的可修改因素.
- 虽然补充剂显示了相关性,但这项回顾性研究不能推断因果关系.
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