营养状况与淋巴结转移在头部和部状细胞癌中的淋巴结转移外节延伸之间的关联
Kornél Dános1, Mátyás Majoros1, Lili Tóth1
1Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Semmelweis University, 1085 Budapest, Hungary.
Nutrients
|February 27, 2026
概括
在头癌中,外节延伸 (ENE) 与患者的营养状况无关,包括BMI和PNI. 在HNSCC患者中,ENE仍然是减少存活时间的重要预测指标.
科学领域:
- 在瘤学瘤学.
- 头部和部手术 头部和部手术
- 癌症预后 癌症预后
背景情况:
- 外节延伸 (ENE) 是已知的头部和部状细胞癌 (HNSCC) 的不良预后因素.
- 通过预后营养指数 (PNI) 和体重指数 (BMI) 评估的营养状况会影响HNSCC的结果.
- 在HNSCC中,ENE和营养状况之间的关系以前没有被探索过.
研究的目的:
- 调查前未接受过治疗的头支状细胞癌 (HNSCC) 患者外节延伸 (ENE) 和营养状况标志物之间的潜在相关性.
- 确定营养指数是否影响ENE的预后意义.
主要方法:
- 对109名患有病理确认结节转移的HNSCC患者进行了回顾性队列研究.
- 通过组织学确定ENE状态;通过BMI,PNI,血清白蛋白和体重减轻来评估营养状况.
- 统计分析包括生存分析 (卡普兰-梅尔,考克斯回归) 和比较测试 (t测试,奇方,ANOVA).
主要成果:
- 外节延伸 (ENE) 存在于54.1%的患者中,并且与减少整体存活率 (p=0.006) 显著相关.
- 在ENE阳性和ENE阴性组之间没有发现BMI,PNI,体重减轻或血清白蛋白的显著差异.
- 根据瘤亚部位 (p=0.018),ENE患病率因瘤亚部位而异 (p=0.018),下腺癌患病率最高 (75.8%),口腔瘤患病率最低 (25.0%).
结论:
- 外节延伸 (ENE) 是HNSCC中的一个重要的独立预后标志物.
- ENE状态似乎不受常见的营养标记的影响或与它们无关.
- 跨瘤亚部位的ENE患病率的异质性表明需要量身定制的管理策略.
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